Difference between revisions of "Thiotepa (Thioplex)"
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(Created page with "==General information== Class/mechanism: <ref name="insert">[http://patient.cancerconsultants.com/druginserts/Thiotepa.pdf Thiotepa (Thioplex) package insert]</ref><ref>[http://h...") |
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| + | Also known as TESPA, Thiophosphoamide, or TSPA. | ||
| + | |||
==General information== | ==General information== | ||
| − | Class/mechanism: <ref name="insert">[http://patient.cancerconsultants.com/druginserts/Thiotepa.pdf Thiotepa (Thioplex) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/thiotepa.pdf Thiotepa (Thioplex) package insert (locally hosted backup)]</ref> | + | Class/mechanism: Alkylator, ethylenimine-type, similar to nitrogen mustards. Ethylenimine radicals are released, which alkylates at the N7 position of guanine, resulting in the linkage between the purine and sugar being severed, and subsequent cell damage and death.<ref name="insert">[http://patient.cancerconsultants.com/druginserts/Thiotepa.pdf Thiotepa (Thioplex) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/thiotepa.pdf Thiotepa (Thioplex) package insert (locally hosted backup)]</ref> |
| − | <br>Route: | + | <br>Route: IV, intravesicular, intracavitary |
| − | <br>Extravasation: | + | <br>Extravasation: [[irritant]] |
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the package insert<ref name="insert"></ref>. | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the package insert<ref name="insert"></ref>. | ||
==Patient drug information== | ==Patient drug information== | ||
| − | *[http://chemocare.com/bio/thiotepa. | + | *[http://chemocare.com/bio/thiotepa.asp Thiotepa (Thioplex) patient drug information (Chemocare)]<ref>[http://chemocare.com/bio/thiotepa.asp Thiotepa (Thioplex) patient drug information (Chemocare)]</ref> |
*[http://www.uptodate.com/contents/thiotepa-patient-drug-information Thiotepa (Thioplex) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/thiotepa-patient-drug-information Thiotepa (Thioplex) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/thiotepa-patient-drug-information Thiotepa (Thioplex) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/thiotepa-patient-drug-information Thiotepa (Thioplex) patient drug information (UpToDate)]</ref> | ||
==References== | ==References== | ||
<references/> | <references/> | ||
Revision as of 00:17, 25 February 2012
Also known as TESPA, Thiophosphoamide, or TSPA.
General information
Class/mechanism: Alkylator, ethylenimine-type, similar to nitrogen mustards. Ethylenimine radicals are released, which alkylates at the N7 position of guanine, resulting in the linkage between the purine and sugar being severed, and subsequent cell damage and death.[1][2]
Route: IV, intravesicular, intracavitary
Extravasation: irritant
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the package insert[1].
Patient drug information
- Thiotepa (Thioplex) patient drug information (Chemocare)[3]
- Thiotepa (Thioplex) patient drug information (UpToDate)[4]