Difference between revisions of "Temozolomide (Temodar)"
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(Created page with "==General information== Class/mechanism: <ref name="insert">[http://www.spfiles.com/pitemodar.pdf Temozolmide (Temodar) package insert]</ref><ref>[http://hemonc.org/docs/packagei...") |
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==General information== | ==General information== | ||
| − | Class/mechanism: <ref name="insert">[http://www.spfiles.com/pitemodar.pdf | + | Class/mechanism: Alkylator. Temozolmide is converted in vivo to the reactive compound 5-(3-methyltriazen- |
| − | <br>Route: | + | 1-yl)-imidazole-4-carboxamide (MTIC). MTIC causes alkylation of DNA at the O6 and N7 positions of guanine, leading to cell damage and cell death.<ref name="insert">[http://www.spfiles.com/pitemodar.pdf Temozolomide (Temodar) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/temozolomide.pdf Temozolomide (Temodar) package insert (locally hosted backup)]</ref><ref>[http://temodar.com Temodar manufacturer's website]</ref> |
| − | <br>Extravasation: | + | <br>Route: PO, IV |
| + | <br>Extravasation: no information | ||
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the package insert<ref name="insert"></ref>. | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the package insert<ref name="insert"></ref>. | ||
==Patient drug information== | ==Patient drug information== | ||
| − | *[http://chemocare.com/bio/temozolomide. | + | *[http://www.spfiles.com/ppitemodar.pdf Temozolomide (Temodar) patient drug information from manufacturer]<ref>[http://www.spfiles.com/ppitemodar.pdf Temozolomide (Temodar) patient drug information from manufacturer]</ref> |
| − | *[http://www.uptodate.com/contents/ | + | *[http://chemocare.com/bio/temozolomide.asp Temozolomide (Temodar) patient drug information (Chemocare)]<ref>[http://chemocare.com/bio/temozolomide.asp Temozolomide (Temodar) patient drug information (Chemocare)]</ref> |
| + | *[http://www.uptodate.com/contents/temozolomide-patient-drug-information Temozolomide (Temodar) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/temozolomide-patient-drug-information Temozolomide (Temodar) patient drug information (UpToDate)]</ref> | ||
==References== | ==References== | ||
<references/> | <references/> | ||
Revision as of 23:24, 24 February 2012
General information
Class/mechanism: Alkylator. Temozolmide is converted in vivo to the reactive compound 5-(3-methyltriazen-
1-yl)-imidazole-4-carboxamide (MTIC). MTIC causes alkylation of DNA at the O6 and N7 positions of guanine, leading to cell damage and cell death.[1][2][3]
Route: PO, IV
Extravasation: no information
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the package insert[1].
Patient drug information
- Temozolomide (Temodar) patient drug information from manufacturer[4]
- Temozolomide (Temodar) patient drug information (Chemocare)[5]
- Temozolomide (Temodar) patient drug information (UpToDate)[6]
References
- ↑ 1.0 1.1 Temozolomide (Temodar) package insert
- ↑ Temozolomide (Temodar) package insert (locally hosted backup)
- ↑ Temodar manufacturer's website
- ↑ Temozolomide (Temodar) patient drug information from manufacturer
- ↑ Temozolomide (Temodar) patient drug information (Chemocare)
- ↑ Temozolomide (Temodar) patient drug information (UpToDate)