Difference between revisions of "Streptozocin (Zanosar)"
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(Created page with "==General information== Class/mechanism: <ref name="insert">[http://zanosar.com/files/Keocyt_Zanosar_SPC_2010.pdf Streptozocin (Zanosar) package insert]</ref><ref>[http://hemonc....") |
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| + | Also known as STZ. | ||
| + | |||
==General information== | ==General information== | ||
| − | Class/mechanism: <ref name="insert">[http://zanosar.com/files/Keocyt_Zanosar_SPC_2010.pdf Streptozocin (Zanosar) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/streptozocin.pdf Streptozocin (Zanosar) package insert (locally hosted backup)]</ref> | + | Class/mechanism: Nitrosourea, alkylates DNA and RNA, antibiotic oncologic, mechanism not fully understood. Streptozocin has been observed to have greater toxicity to pancreatic islet beta cells, possibly because streptozocin can be transported into beta cells via the glucose transport protein GLUT2.<ref name="insert">[http://zanosar.com/files/Keocyt_Zanosar_SPC_2010.pdf Streptozocin (Zanosar) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/streptozocin.pdf Streptozocin (Zanosar) package insert (locally hosted backup)]</ref><ref>[http://zanosar.com/ Zanosar manufacturer's website]</ref> |
| − | <br>Route: | + | <br>Route: IV |
| − | <br>Extravasation: | + | <br>Extravasation: [[vesicant]] |
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the package insert<ref name="insert"></ref>. | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the package insert<ref name="insert"></ref>. | ||
==Patient drug information== | ==Patient drug information== | ||
| − | *[http://chemocare.com/bio/streptozocin. | + | *[http://zanosar.com/files/Keocyt_Zanosar_PatientLeaflet_2010.pdf Streptozocin (Zanosar) patient drug information from manufacturer]<ref>[http://zanosar.com/files/Keocyt_Zanosar_PatientLeaflet_2010.pdf Streptozocin (Zanosar) patient information from manufacturer]</ref> |
| + | *[http://chemocare.com/bio/streptozocin.asp Streptozocin (Zanosar) patient drug information (Chemocare)]<ref>[http://chemocare.com/bio/streptozocin.asp Streptozocin (Zanosar) patient drug information (Chemocare)]</ref> | ||
*[http://www.uptodate.com/contents/streptozocin-patient-drug-information Streptozocin (Zanosar) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/streptozocin-patient-drug-information Streptozocin (Zanosar) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/streptozocin-patient-drug-information Streptozocin (Zanosar) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/streptozocin-patient-drug-information Streptozocin (Zanosar) patient drug information (UpToDate)]</ref> | ||
==References== | ==References== | ||
<references/> | <references/> | ||
Revision as of 21:23, 24 February 2012
Also known as STZ.
General information
Class/mechanism: Nitrosourea, alkylates DNA and RNA, antibiotic oncologic, mechanism not fully understood. Streptozocin has been observed to have greater toxicity to pancreatic islet beta cells, possibly because streptozocin can be transported into beta cells via the glucose transport protein GLUT2.[1][2][3]
Route: IV
Extravasation: vesicant
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the package insert[1].
Patient drug information
- Streptozocin (Zanosar) patient drug information from manufacturer[4]
- Streptozocin (Zanosar) patient drug information (Chemocare)[5]
- Streptozocin (Zanosar) patient drug information (UpToDate)[6]
References
- ↑ 1.0 1.1 Streptozocin (Zanosar) package insert
- ↑ Streptozocin (Zanosar) package insert (locally hosted backup)
- ↑ Zanosar manufacturer's website
- ↑ Streptozocin (Zanosar) patient information from manufacturer
- ↑ Streptozocin (Zanosar) patient drug information (Chemocare)
- ↑ Streptozocin (Zanosar) patient drug information (UpToDate)