Difference between revisions of "Toripalimab (Loqtorzi)"
Jump to navigation
Jump to search
m |
m |
||
Line 3: | Line 3: | ||
==Diseases for which it is used== | ==Diseases for which it is used== | ||
+ | *[[Bladder cancer]] | ||
*[[Esophageal squamous cell carcinoma]] | *[[Esophageal squamous cell carcinoma]] | ||
+ | *[[Melanoma]] | ||
*[[Nasopharyngeal carcinoma]] | *[[Nasopharyngeal carcinoma]] | ||
*[[Non-small cell lung cancer, nonsquamous]] | *[[Non-small cell lung cancer, nonsquamous]] | ||
Line 16: | Line 18: | ||
[[Category:Anti-PD-1 antibodies]] | [[Category:Anti-PD-1 antibodies]] | ||
+ | [[Category:Bladder cancer medications]] | ||
[[Category:Esophageal squamous cell carcinoma medications]] | [[Category:Esophageal squamous cell carcinoma medications]] | ||
+ | [[Category:Melanoma medications]] | ||
[[Category:Nasopharyngeal carcinoma medications]] | [[Category:Nasopharyngeal carcinoma medications]] | ||
[[Category:Non-small cell lung cancer, nonsquamous medications]] | [[Category:Non-small cell lung cancer, nonsquamous medications]] | ||
[[Category:Non-small cell lung cancer, squamous medications]] | [[Category:Non-small cell lung cancer, squamous medications]] | ||
[[Category:NMPA approved drugs]] | [[Category:NMPA approved drugs]] |
Revision as of 21:45, 6 February 2023
Mechanism of action
From the NCI Drug Dictionary: A humanized immunoglobulin (Ig) G4 monoclonal antibody directed against the negative immunoregulatory human cell surface receptor programmed cell death 1 (programmed death-1; PD-1), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, toripalimab binds to PD-1 and inhibits the binding of PD-1 to its ligands, programmed cell death-1 ligand 1 (PD-L1) and PD-1 ligand 2 (PD-L2). This prevents the activation of PD-1 and its downstream signaling pathways. This may restore immune function through the activation of both T cells and T-cell-mediated immune responses against tumor cells.
Diseases for which it is used
- Bladder cancer
- Esophageal squamous cell carcinoma
- Melanoma
- Nasopharyngeal carcinoma
- Non-small cell lung cancer, nonsquamous
- Non-small cell lung cancer, squamous
Also known as
- Code name: JS001
- Brand name: Tuoyi