Difference between revisions of "Cladribine (Leustatin)"
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| + | Also known as 2-chlorodeoxyadenosine. | ||
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==General information== | ==General information== | ||
Class/mechanism: Purine analog; mimics the nucleoside adenosine, inhibiting adenosine deaminase, which interferes with DNA synthesis and repair.<ref name="insert">[http://www.janssenbiotech.com/assets/Leustatin_PI.pdf Cladribine (Leustatin)) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/cladribine.pdf Cladribine (Leustatin) package insert (locally hosted backup)]</ref> | Class/mechanism: Purine analog; mimics the nucleoside adenosine, inhibiting adenosine deaminase, which interferes with DNA synthesis and repair.<ref name="insert">[http://www.janssenbiotech.com/assets/Leustatin_PI.pdf Cladribine (Leustatin)) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/cladribine.pdf Cladribine (Leustatin) package insert (locally hosted backup)]</ref> | ||
Revision as of 06:51, 21 February 2012
Also known as 2-chlorodeoxyadenosine.
General information
Class/mechanism: Purine analog; mimics the nucleoside adenosine, inhibiting adenosine deaminase, which interferes with DNA synthesis and repair.[1][2]
Route: IV
Extravasation: irritant
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the package insert[1].
Patient drug information
- Cladribine (Leustatin) patient drug information (Chemocare)[3]
- Cladribine (Leustatin) patient drug information (UpToDate)[4]