Difference between revisions of "Finasteride (Proscar)"
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(Created page with "==General information== Class/mechanism: <ref name="insert">[http://www.merck.com/product/usa/pi_circulars/p/proscar/proscar_pi.pdf Finasteride (Proscar) package insert]</ref><re...") |
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==General information== | ==General information== | ||
| − | Class/mechanism: <ref name="insert">[http://www.merck.com/product/usa/pi_circulars/p/proscar/proscar_pi.pdf Finasteride (Proscar) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/finasteride.pdf Finasteride (Proscar) package insert (locally hosted backup)]</ref> | + | Class/mechanism: 5 alpha-reductase inhibitor; inhibits conversion of testosterone to dihydrotestosterone (DHT). Specifically and competitively inhibits Type II 5α-reductase by forming a stable enzyme-drug complex.<ref name="insert">[http://www.merck.com/product/usa/pi_circulars/p/proscar/proscar_pi.pdf Finasteride (Proscar) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/finasteride.pdf Finasteride (Proscar) package insert (locally hosted backup)]</ref> |
| − | <br>Route: | + | <br>Route: PO |
| − | <br>Extravasation: | + | <br>Extravasation: n/a |
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the package insert<ref name="insert"></ref>. | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the package insert<ref name="insert"></ref>. | ||
Revision as of 23:44, 15 January 2012
General information
Class/mechanism: 5 alpha-reductase inhibitor; inhibits conversion of testosterone to dihydrotestosterone (DHT). Specifically and competitively inhibits Type II 5α-reductase by forming a stable enzyme-drug complex.[1][2]
Route: PO
Extravasation: n/a
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the package insert[1].