Capmatinib (Tabrecta)

General information

Class/mechanism: Small molecule tyrosine kinase inhibitor, oral cMET inhibitor. Inhibits MET (mesenchymal-epithelial transition), including the mutant variant which results from exon 14 skipping. Cells with MET exon 14 skipping have a protein with a missing regulatory domain, which results in reduced negative regulation and therefore increased downstream MET signaling. Capmatinib was demonstrated to inhibit cancer cell growth driven by a mutant MET variant lacking exon 14.
Route: PO
Extravasation: n/a

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Diseases for which it is used

• Non-small cell lung cancer, MET-mutated

Patient drug information

• Capmatinib (Tabrecta) package insert

History of changes in FDA indication

• 5/6/2020: FDA accelerated approval for the treatment of adult patients with metastatic non-small cell lung cancer (NSCLC) whose tumors have a mutation that leads to mesenchymal-epithelial transition (MET) exon 14 skipping as detected by an FDA-approved test. (Based on GEOMETRY mono-1)

Also known as

• Code names: INC280
• Generic name: capmatinib
• Brand names: Tabrecta