Difference between revisions of "User talk:Binunair2002"
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− | = | + | = LGL with treatment indications= |
− | == Methotrexate | + | |
− | *[[Methotrexate 10mg/m2 weekly po]] + | + | Regimen 1 |
− | *[[ Prednisone 1mg/kg po daily x one month then taper over 1 months.]] | + | == Methotrexate +/- Prednisone== |
− | ''' stop if no response by 4 months, if response continue ''' | + | *[[Methotrexate 7.5mg/m2 to 10mg/m2 weekly po]] + |
+ | *[[Prednisone 1mg/kg po daily x one month then taper over 1 months.]] | ||
+ | ''' stop if no response by 4 months, if response continue until progression ''' | ||
+ | |||
+ | Supportive medications: | ||
+ | |||
+ | ===References=== | ||
+ | |||
+ | # Bareau B, Rey J, Hamidou M, et al. Analysis of a French cohort of patients with large granular lymphocyte leukemia: a report on 229 cases. Haematologica 2010;95(9):1534-1541.[http://www.haematologica.org/content/95/9/1534.long#T3 long link to original article] [http://www.ncbi.nlm.nih.gov/pubmed?term=20378561 pubmed] | ||
+ | # Lamy T, Loughran TP.[http://www.ncbi.nlm.nih.gov/pubmed?term=21190991 ] How I treat LGL leukemia. Blood 2011; 117: 2764–2774.[http://www.ncbi.nlm.nih.gov/pubmed?term=21190991 link to original artcle ][http://www.ncbi.nlm.nih.gov/pubmed?term=21190991 pubmed] | ||
+ | |||
+ | Regimen 1 | ||
+ | ==Cyclophosphamide +/- Prednisone== | ||
+ | *[[ Cyclophosphamide 50-100 mg po daily | ||
+ | '''stop if no response by 4 months, if response continue for 6-12 months ,earlier if progression. Generous po fluid intake to prevent bladder toxicity''' | ||
+ | |||
+ | ===References=== | ||
+ | |||
+ | # Bareau B, Rey J, Hamidou M, et al. Analysis of a French cohort of patients with large granular lymphocyte leukemia: a report on 229 cases. Haematologica 2010;95(9):1534-1541.[http://www.haematologica.org/content/95/9/1534.long#T3 long link to original article] [http://www.ncbi.nlm.nih.gov/pubmed?term=20378561 pubmed] | ||
+ | # Lamy T, Loughran TP.[http://www.ncbi.nlm.nih.gov/pubmed?term=21190991 ] How I treat LGL leukemia. Blood 2011; 117: 2764–2774.[http://www.ncbi.nlm.nih.gov/pubmed?term=21190991 link to original article ][http://www.ncbi.nlm.nih.gov/pubmed?term=21190991 pubmed] | ||
+ | #Go RS, Li CY, Tefferi A, Phyliky RL(2001) Acquired pure red cell aplasia associated with lymphoproliferative disease of granular T lymphocytes. Blood 98:483–5 [http://bloodjournal.hematologylibrary.org/content/98/2/483.long link to original article ] [http://www.ncbi.nlm.nih.gov/pubmed?term=11435321 pubmed ] |
Revision as of 03:41, 18 April 2014
LGL with treatment indications
Regimen 1
Methotrexate +/- Prednisone
- Methotrexate 7.5mg/m2 to 10mg/m2 weekly po +
- Prednisone 1mg/kg po daily x one month then taper over 1 months.
stop if no response by 4 months, if response continue until progression
Supportive medications:
References
- Bareau B, Rey J, Hamidou M, et al. Analysis of a French cohort of patients with large granular lymphocyte leukemia: a report on 229 cases. Haematologica 2010;95(9):1534-1541.long link to original article pubmed
- Lamy T, Loughran TP.[1] How I treat LGL leukemia. Blood 2011; 117: 2764–2774.link to original artcle pubmed
Regimen 1
Cyclophosphamide +/- Prednisone
- [[ Cyclophosphamide 50-100 mg po daily
stop if no response by 4 months, if response continue for 6-12 months ,earlier if progression. Generous po fluid intake to prevent bladder toxicity
References
- Bareau B, Rey J, Hamidou M, et al. Analysis of a French cohort of patients with large granular lymphocyte leukemia: a report on 229 cases. Haematologica 2010;95(9):1534-1541.long link to original article pubmed
- Lamy T, Loughran TP.[2] How I treat LGL leukemia. Blood 2011; 117: 2764–2774.link to original article pubmed
- Go RS, Li CY, Tefferi A, Phyliky RL(2001) Acquired pure red cell aplasia associated with lymphoproliferative disease of granular T lymphocytes. Blood 98:483–5 link to original article pubmed