Difference between revisions of "Ixabepilone (Ixempra)"
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==General information== | ==General information== | ||
| − | Class/mechanism: Microtubule inhibitor; semi-synthetic analog of epothilone B. Ixabepilone binds to beta tubulin on microtubules, suppresses the dynamic instability of alpha beta II and alpha beta III, and disrupts normal microtubule dynamics. This results in arrest in the mitotic phase of the cell cycle and cell death.<ref name="insert">[http://packageinserts.bms.com/pi/pi_ixempra.pdf Ixabepilone (Ixempra) package insert]</ref><ref>[ | + | Class/mechanism: Microtubule inhibitor; semi-synthetic analog of epothilone B. Ixabepilone binds to beta tubulin on microtubules, suppresses the dynamic instability of alpha beta II and alpha beta III, and disrupts normal microtubule dynamics. This results in arrest in the mitotic phase of the cell cycle and cell death.<ref name="insert">[http://packageinserts.bms.com/pi/pi_ixempra.pdf Ixabepilone (Ixempra) package insert]</ref><ref>[[Media:Ixabepilone.pdf | Ixabepilone (Ixempra) package insert (locally hosted backup)]]</ref><ref>[http://www.ixempra.com/ Ixempra manufacturer's site]</ref> |
<br>Route: IV | <br>Route: IV | ||
| − | <br>Extravasation: | + | <br>Extravasation: [[irritant]] |
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | ||
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==Patient drug information== | ==Patient drug information== | ||
*[http://packageinserts.bms.com/pi/pi_ixempra.pdf#page=8 Ixabepilone (Ixempra) patient drug information]<ref>[http://packageinserts.bms.com/pi/pi_ixempra.pdf#page=8 Ixabepilone (Ixempra) patient drug information]</ref> | *[http://packageinserts.bms.com/pi/pi_ixempra.pdf#page=8 Ixabepilone (Ixempra) patient drug information]<ref>[http://packageinserts.bms.com/pi/pi_ixempra.pdf#page=8 Ixabepilone (Ixempra) patient drug information]</ref> | ||
| − | *[http://chemocare.com/ | + | *[http://chemocare.com/chemotherapy/drug-info/ixabepilone.aspx Ixabepilone (Ixempra) patient drug information (Chemocare)]<ref>[http://chemocare.com/chemotherapy/drug-info/ixabepilone.aspx Ixabepilone (Ixempra) patient drug information (Chemocare)]</ref> |
*[http://www.uptodate.com/contents/ixabepilone-patient-drug-information Ixabepilone (Ixempra) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/ixabepilone-patient-drug-information Ixabepilone (Ixempra) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/ixabepilone-patient-drug-information Ixabepilone (Ixempra) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/ixabepilone-patient-drug-information Ixabepilone (Ixempra) patient drug information (UpToDate)]</ref> | ||
==References== | ==References== | ||
<references/> | <references/> | ||
| + | |||
| + | [[Category:Drug index]] | ||
| + | [[Category:Chemotherapy]] | ||
| + | |||
| + | [[Category:Irritant chemotherapy]] | ||
| + | [[Category:Microtubule inhibitors]] | ||
| + | [[Category:Breast cancer medications]] | ||
Revision as of 03:28, 16 August 2013
General information
Class/mechanism: Microtubule inhibitor; semi-synthetic analog of epothilone B. Ixabepilone binds to beta tubulin on microtubules, suppresses the dynamic instability of alpha beta II and alpha beta III, and disrupts normal microtubule dynamics. This results in arrest in the mitotic phase of the cell cycle and cell death.[1][2][3]
Route: IV
Extravasation: irritant
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
Patient drug information
- Ixabepilone (Ixempra) patient drug information[4]
- Ixabepilone (Ixempra) patient drug information (Chemocare)[5]
- Ixabepilone (Ixempra) patient drug information (UpToDate)[6]
References
- ↑ 1.0 1.1 Ixabepilone (Ixempra) package insert
- ↑ Ixabepilone (Ixempra) package insert (locally hosted backup)
- ↑ Ixempra manufacturer's site
- ↑ Ixabepilone (Ixempra) patient drug information
- ↑ Ixabepilone (Ixempra) patient drug information (Chemocare)
- ↑ Ixabepilone (Ixempra) patient drug information (UpToDate)