Rucaparib (Rubraca)

General information

Class/mechanism: PARP inhibitor. Rucaparib inhibits activity of the poly (ADP-ribose) polymerase (PARP) enzymes--including PARP-1, PARP-2, and PARP-3--and interferes with PARP-mediated DNA repair. PARP inhibitor cytotoxicity is believed to involve formation of PARP-DNA complexes, DNA damage, apotosis, and cell death. This cytotoxicity was observed to have increased cytotoxicity in cells with mutations in BRCA1, BRCA2, and other DNA repair genes.
Route: PO
Extravasation: n/a

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Diseases for which it is used

• Ovarian cancer

Patient drug information

• Rucaparib (Rubraca) package insert

History of changes in FDA indication

• 12/19/2016: FDA granted accelerated approval "for treatment of patients with deleterious BRCA mutation (germline and/or somatic) associated advanced ovarian cancer who have been treated with two or more chemotherapies."
• 4/6/2018: FDA approved "for the maintenance treatment of recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in a complete or partial response to platinum-based chemotherapy."

Also known as

• Code names: CO-338, AG-014699, PF-0136738
• Brand name: Rubraca