Difference between revisions of "Cytarabine (Ara-C)"
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==General information== | ==General information== | ||
Class/mechanism: Pyrimidine analog, mimics cytosine. Converted intracellularly into cytarabine-5-triphosphate (ara-CTP). Exact mechanism of action not known; believed to inhibit DNA polymerase, incorporate into DNA and RNA, and kill cells undergoing DNA synthesis (S-phase) and sometimes block cells from progressing from the G1 phase to the S-phase.<ref name="insert">[http://www.hospira.com/_docs/Cytarabine%20483176-PROMOWEB.pdf Cytarabine (Cytosar) package insert]</ref><ref>[[Media:Cytarabine.pdf | Cytarabine (Cytosar) package insert (locally hosted backup)]]</ref> | Class/mechanism: Pyrimidine analog, mimics cytosine. Converted intracellularly into cytarabine-5-triphosphate (ara-CTP). Exact mechanism of action not known; believed to inhibit DNA polymerase, incorporate into DNA and RNA, and kill cells undergoing DNA synthesis (S-phase) and sometimes block cells from progressing from the G1 phase to the S-phase.<ref name="insert">[http://www.hospira.com/_docs/Cytarabine%20483176-PROMOWEB.pdf Cytarabine (Cytosar) package insert]</ref><ref>[[Media:Cytarabine.pdf | Cytarabine (Cytosar) package insert (locally hosted backup)]]</ref> | ||
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*[http://chemocare.com/chemotherapy/drug-info/cytarabine.aspx Cytarabine (Cytosar) patient drug information (Chemocare)]<ref>[http://chemocare.com/chemotherapy/drug-info/cytarabine.aspx Cytarabine (Cytosar) patient drug information (Chemocare)]</ref> | *[http://chemocare.com/chemotherapy/drug-info/cytarabine.aspx Cytarabine (Cytosar) patient drug information (Chemocare)]<ref>[http://chemocare.com/chemotherapy/drug-info/cytarabine.aspx Cytarabine (Cytosar) patient drug information (Chemocare)]</ref> | ||
*[http://www.uptodate.com/contents/cytarabine-patient-drug-information Cytarabine (Cytosar) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/cytarabine-patient-drug-information Cytarabine (Cytosar) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/cytarabine-patient-drug-information Cytarabine (Cytosar) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/cytarabine-patient-drug-information Cytarabine (Cytosar) patient drug information (UpToDate)]</ref> | ||
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| + | ==Also known as== | ||
| + | Alcysten, Alexan, Alexan 100, ARA, Ara-C, Arabine, Arabinosylcytosine, Arabitin, ARA Cell, Aracitin, Aracytin, Aracytine, Arabinofuranosyl Cytidine, Citagenin, Citaloxan, Citarabin, Citarabina, Citarabina Filaxis, Citarabina Martian, Citarabina Pharmacia, Citarabins, Citarax, Cylocide, Cylocide-N, Cytarabin, Cytarabin CS, Cytarabine, Cytarabine BVI, Cytarabine Comp, Cytarabine DBL, Cytarabine Faulding, Cytarabine FOT, Cytarabine Hydrochloride, Cytarabine Mayne Onco-Tain, Cytarabine Ocfosfate, Cytarabine Pfizer, Cytarabins, Cytarabinum, Cytarbel, Cytarine, Cytosar, Cytosar-U, Cytosine Arabinoside, Cytrosar, Depocyt, Depocyte, Erbabin, Erpalfa, Fauldcita, Groven, Ifarab, Iretin, Laracit, Medsara, Novutrax, P&U Cytarabine, Remcyta, Starasid, Tabin, Tabine, Trav Cytarabine, Udicil. | ||
==References== | ==References== | ||
Revision as of 03:44, 16 May 2013
General information
Class/mechanism: Pyrimidine analog, mimics cytosine. Converted intracellularly into cytarabine-5-triphosphate (ara-CTP). Exact mechanism of action not known; believed to inhibit DNA polymerase, incorporate into DNA and RNA, and kill cells undergoing DNA synthesis (S-phase) and sometimes block cells from progressing from the G1 phase to the S-phase.[1][2]
Route: IV, IT, SC
Extravasation: no information
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
- Acute lymphocytic leukemia
- Acute myeloid leukemia
- Chronic lymphocytic leukemia (CLL) and Small lymphocytic lymphoma (SLL)
- Hodgkin lymphoma
- Non-Hodgkin lymphoma
- Transplant conditioning regimens
Patient drug information
- Cytarabine (Cytosar) patient drug information (Chemocare)[3]
- Cytarabine (Cytosar) patient drug information (UpToDate)[4]
Also known as
Alcysten, Alexan, Alexan 100, ARA, Ara-C, Arabine, Arabinosylcytosine, Arabitin, ARA Cell, Aracitin, Aracytin, Aracytine, Arabinofuranosyl Cytidine, Citagenin, Citaloxan, Citarabin, Citarabina, Citarabina Filaxis, Citarabina Martian, Citarabina Pharmacia, Citarabins, Citarax, Cylocide, Cylocide-N, Cytarabin, Cytarabin CS, Cytarabine, Cytarabine BVI, Cytarabine Comp, Cytarabine DBL, Cytarabine Faulding, Cytarabine FOT, Cytarabine Hydrochloride, Cytarabine Mayne Onco-Tain, Cytarabine Ocfosfate, Cytarabine Pfizer, Cytarabins, Cytarabinum, Cytarbel, Cytarine, Cytosar, Cytosar-U, Cytosine Arabinoside, Cytrosar, Depocyt, Depocyte, Erbabin, Erpalfa, Fauldcita, Groven, Ifarab, Iretin, Laracit, Medsara, Novutrax, P&U Cytarabine, Remcyta, Starasid, Tabin, Tabine, Trav Cytarabine, Udicil.
References
- Drug index
- Chemotherapy
- Nucleic acid analogs
- DNA synthesis inhibitors
- Acute lymphocytic leukemia medications
- Acute myeloid leukemia medications
- Chronic lymphocytic leukemia (CLL) and Small lymphocytic lymphoma (SLL) medications
- Hodgkin lymphoma medications
- Non-Hodgkin lymphoma medications
- Transplant medications