Difference between revisions of "Amsacrine (Amsidine)"
Jump to navigation
Jump to search
m (categories) |
m |
||
| Line 13: | Line 13: | ||
[[Category:Drug index]] | [[Category:Drug index]] | ||
| + | [[Category:Orphan drug]] | ||
[[Category:Chemotherapy]] | [[Category:Chemotherapy]] | ||
| + | [[Category:Vesicant chemotherapy]] | ||
| + | |||
[[Category:DNA synthesis inhibitors]] | [[Category:DNA synthesis inhibitors]] | ||
| − | [[Category: | + | [[Category:Topoisomerase inhibitors]] |
Revision as of 14:39, 1 November 2014
General information
Class/mechanism: Synthetic acridine-derivate. Exact mechanism unclear; amsacrine binds to DNA by intercalation and external electrostatic binding, which inhibits DNA synthesis and causes DNA fragmentation.[1][2]
Route: IV
Extravasation: vesicant
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]