Difference between revisions of "Example orders for simplified biweekly 5-FU & leucovorin (sLV5FU2) in colon cancer"
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==Simplified biweekly 5-FU & leucovorin (sLV5FU2)== | ==Simplified biweekly 5-FU & leucovorin (sLV5FU2)== | ||
| − | Original | + | Original references may be found at [[Colon_cancer#Fluorouracil_.285-FU.29_.26_Folinic_acid_.28Leucovorin.29_2|simplified biweekly 5-FU & leucovorin (sLV5FU2)]] |
===Example regimen #1=== | ===Example regimen #1=== | ||
Revision as of 16:43, 3 July 2012
Use of this site is subject to you reading and agreeing with the terms set forth in the disclaimer.
Simplified biweekly 5-FU & leucovorin (sLV5FU2)
Original references may be found at simplified biweekly 5-FU & leucovorin (sLV5FU2)
Example regimen #1
- Folinic acid (Leucovorin) 400 mg/m2 IV over 2 hours on days 1 & 15, given first
- Fluorouracil (5-FU) 400 mg/m2 IV bolus over 10-15 minutes on day 1 after leucovorin
- Fluorouracil (5-FU) 1200 mg/m2/day (total dose of 2400 mg/m2) IV continuous infusion over 46 hours on days 1-2, to start after 5-FU bolus
28-day cycles
Supportive medications:
- Dexamethasone (Decadron) 12 mg PO 30 minutes prior to chemotherapy
- Ondansetron (Zofran) 16 mg IV 30 minutes prior to chemotherapy
- Lorazepam (Ativan) 0.5-1 mg PO prn nausea/anxiety, given 30 minutes prior to chemotherapy
Hydration:
- 500 ml D5W at KVO rate as running IV for chemotherapy infusion. Give up to 500 ml D5W.
Monitoring:
- Hold if ANC <1500 or platelets <75 and notify physician.
- Comprehensive metabolic panel (chem 10 & LFTs) before each treatment
- Monitor for possible hand-foot syndrome
- Assess for mucositis at every visit
Comments:
- My institution administers this regimen in 28-day cycles.