Difference between revisions of "Pentostatin (Nipent)"
Warner-admin (talk | contribs) m (Text replacement - "Category:Intravenous chemotherapy" to "Category:Intravenous medications") |
Warner-admin (talk | contribs) m (Text replacement - "Chronic lymphocytic leukemia (CLL) and Small lymphocytic lymphoma (SLL)" to "Chronic lymphocytic leukemia (CLL/SLL)") |
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==Diseases for which it is used== | ==Diseases for which it is used== | ||
| − | *[[Chronic lymphocytic leukemia (CLL | + | *[[Chronic lymphocytic leukemia (CLL/SLL)]] |
*[[Hairy cell leukemia]] | *[[Hairy cell leukemia]] | ||
*[[Waldenström macroglobulinemia]] | *[[Waldenström macroglobulinemia]] | ||
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[[Category:Purine analogues]] | [[Category:Purine analogues]] | ||
| − | [[Category:Chronic lymphocytic leukemia (CLL | + | [[Category:Chronic lymphocytic leukemia (CLL/SLL) medications]] |
[[Category:Hairy cell leukemia medications]] | [[Category:Hairy cell leukemia medications]] | ||
[[Category:Waldenström macroglobulinemia medications]] | [[Category:Waldenström macroglobulinemia medications]] | ||
[[Category:Drugs FDA approved in 1991]] | [[Category:Drugs FDA approved in 1991]] | ||
Revision as of 14:57, 14 October 2017
General information
Class/mechanism: Purine (adenosine) analog, inhibitor of adenosine deaminase (ADA), causes elevated intracellular levels of dATP, and inhibits ribonucleotide reductase, which interferes with DNA synthesis. Pentostatin can also inhibit RNA synthesis and has been observed to cause DNA damage. ADA enzymatic activity is greater in T-cell malignancies compared to B-cell malignancies. Exact mechanism of action in hairy cell leukemia is not fully understood.[1][2][3]
Route: IV
Extravasation: neutral
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
Patient drug information
- Pentostatin (Nipent) patient drug information (Chemocare)[4]
- Pentostatin (Nipent) patient drug information (UpToDate)[5]
History of changes in FDA indication
- 10/11/1991: Initial FDA approval
Also known as
2'-deoxycoformycin or dCF.