Difference between revisions of "Pegylated liposomal doxorubicin (Doxil)"
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| − | Also known as Caelyx. | + | Also known as Caelyx or Myocet. |
==General information== | ==General information== | ||
Class/mechanism: Anthracycline; binds and intercalates into DNA, inhibiting nucleotide replication and DNA/RNA polymerase activity. Causes DNA cleavage through interaction with topoisomerase II. | Class/mechanism: Anthracycline; binds and intercalates into DNA, inhibiting nucleotide replication and DNA/RNA polymerase activity. Causes DNA cleavage through interaction with topoisomerase II. | ||
| − | Doxorubicin is encapsulated in long-circulating STEALTH® liposomes, which are microscopic vesicles made of a phospholipid bilayer. The liposomes are pegylated with surface-bound methoxypolyethylene glycol (MPEG) to increase circulation time and protect them from detection by the mononuclear phagocyte system (MPS). Their 100 nm size and long circulation may aid their ability to penetrate the altered vasculature of tumors. Exact mechanism of release of the active drug contained within the liposome is not understood.<ref name="insert">[http://www.doxil.com/assets/DOXIL_PI_Booklet.pdf Doxorubicin liposomal (Doxil) package insert]</ref><ref>[ | + | Doxorubicin is encapsulated in long-circulating STEALTH® liposomes, which are microscopic vesicles made of a phospholipid bilayer. The liposomes are pegylated with surface-bound methoxypolyethylene glycol (MPEG) to increase circulation time and protect them from detection by the mononuclear phagocyte system (MPS). Their 100 nm size and long circulation may aid their ability to penetrate the altered vasculature of tumors. Exact mechanism of release of the active drug contained within the liposome is not understood.<ref name="insert">[http://www.doxil.com/assets/DOXIL_PI_Booklet.pdf Doxorubicin liposomal (Doxil) package insert]</ref><ref>[[Media:Doxorubicinliposomal.pdf | Doxorubicin liposomal (Doxil) package insert (locally hosted backup)]]</ref><ref>[http://doxil.com/ Doxil manufacturer's website]</ref> |
<br>Route: IV | <br>Route: IV | ||
<br>Extravasation: [[irritant]] | <br>Extravasation: [[irritant]] | ||
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | ||
| + | |||
| + | ==Diseases for which it is used== | ||
| + | *[[Breast cancer]] | ||
| + | *[[Esophageal cancer]] | ||
| + | *[[Hodgkin lymphoma]] | ||
| + | *[[Multiple myeloma]] | ||
| + | *[[Ovarian cancer]] | ||
==Patient drug information== | ==Patient drug information== | ||
| − | *[http://chemocare.com/ | + | *[http://chemocare.com/chemotherapy/drug-info/doxorubicin-liposomal.aspx Doxorubicin liposomal (Doxil) patient drug information (Chemocare)]<ref>[http://chemocare.com/chemotherapy/drug-info/doxorubicin-liposomal.aspx Doxorubicin liposomal (Doxil) patient drug information (Chemocare)]</ref> |
| + | *Brief patient counseling information can be found on [http://www.doxil.com/assets/DOXIL_PI_Booklet.pdf#page=15 page 15 of the Doxorubicin liposomal (Doxil) package insert]<ref name="insert"></ref> | ||
*[http://www.uptodate.com/contents/liposomal-doxorubicin-patient-drug-information Doxorubicin liposomal (Doxil) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/liposomal-doxorubicin-patient-drug-information Doxorubicin liposomal (Doxil) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/liposomal-doxorubicin-patient-drug-information Doxorubicin liposomal (Doxil) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/liposomal-doxorubicin-patient-drug-information Doxorubicin liposomal (Doxil) patient drug information (UpToDate)]</ref> | ||
==References== | ==References== | ||
<references/> | <references/> | ||
| + | |||
| + | [[Category:Drug index]] | ||
| + | [[Category:Chemotherapy]] | ||
| + | [[Category:Anthracyclines]] | ||
| + | [[Category:Topoisomerase inhibitors]] | ||
| + | [[Category:Irritant chemotherapy]] | ||
| + | [[Category:Breast cancer medications]] | ||
| + | [[Category:Esophageal cancer medications]] | ||
| + | [[Category:Hodgkin lymphoma medications]] | ||
| + | [[Category:Multiple myeloma medications]] | ||
| + | [[Category:Ovarian cancer medications]] | ||
Revision as of 04:50, 15 October 2012
Also known as Caelyx or Myocet.
General information
Class/mechanism: Anthracycline; binds and intercalates into DNA, inhibiting nucleotide replication and DNA/RNA polymerase activity. Causes DNA cleavage through interaction with topoisomerase II.
Doxorubicin is encapsulated in long-circulating STEALTH® liposomes, which are microscopic vesicles made of a phospholipid bilayer. The liposomes are pegylated with surface-bound methoxypolyethylene glycol (MPEG) to increase circulation time and protect them from detection by the mononuclear phagocyte system (MPS). Their 100 nm size and long circulation may aid their ability to penetrate the altered vasculature of tumors. Exact mechanism of release of the active drug contained within the liposome is not understood.[1][2][3]
Route: IV
Extravasation: irritant
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
Patient drug information
- Doxorubicin liposomal (Doxil) patient drug information (Chemocare)[4]
- Brief patient counseling information can be found on page 15 of the Doxorubicin liposomal (Doxil) package insert[1]
- Doxorubicin liposomal (Doxil) patient drug information (UpToDate)[5]