Difference between revisions of "Nelarabine (Arranon)"
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For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | ||
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| + | ==Diseases for which it is used== | ||
| + | [[Acute lymphocytic leukemia | T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma]] | ||
==Patient drug information== | ==Patient drug information== | ||
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*[http://chemocare.com/bio/nelarabine.asp Nelarabine (Arranon) patient drug information (Chemocare)]<ref>[http://chemocare.com/bio/nelarabine.asp Nelarabine (Arranon) patient drug information (Chemocare)]</ref> | *[http://chemocare.com/bio/nelarabine.asp Nelarabine (Arranon) patient drug information (Chemocare)]<ref>[http://chemocare.com/bio/nelarabine.asp Nelarabine (Arranon) patient drug information (Chemocare)]</ref> | ||
*[http://www.uptodate.com/contents/nelarabine-patient-drug-information Nelarabine (Arranon) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/nelarabine-patient-drug-information Nelarabine (Arranon) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/nelarabine-patient-drug-information Nelarabine (Arranon) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/nelarabine-patient-drug-information Nelarabine (Arranon) patient drug information (UpToDate)]</ref> | ||
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| + | ==History of changes in FDA indication== | ||
| + | * 10/28/2005: Initial FDA approval "for the treatment of patients with [[Acute lymphocytic leukemia | T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma]] whose disease has not responded to or has relapsed following treatment with at least two chemotherapy regimens." | ||
==References== | ==References== | ||
<references/> | <references/> | ||
| + | [[Category:Drug index]][[Category:Chemotherapy]][[Category:Antimetabolites]][[Category:Purine analogues]][[Category:Acute lymphocytic leukemia medications]][[Category:Drugs FDA approved in 2005]] | ||
Revision as of 22:52, 4 November 2014
Also known as Atriance.
General information
Class/mechanism: Purine analog, antimetabolite. Nelarabine is metabolized to the cytotoxic deoxyguanosine analogue, 9-β-Darabinofuranosylguanine (ara-G), which is eventually converted to ara-GTP. ara-GTP is incorporated into DNA and leads to inhibition of DNA synthesis and cell death.[1][2]
Route: IV
Extravasation: no information
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma
Patient drug information
- Nelarabine (Arranon) package insert PDF pages 17-19[1]
- Nelarabine (Arranon) patient drug information (Chemocare)[3]
- Nelarabine (Arranon) patient drug information (UpToDate)[4]
History of changes in FDA indication
- 10/28/2005: Initial FDA approval "for the treatment of patients with T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma whose disease has not responded to or has relapsed following treatment with at least two chemotherapy regimens."