Difference between revisions of "Degarelix (Firmagon)"
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| + | Also known as degarelix acetate or FE200486. | ||
| + | |||
==General information== | ==General information== | ||
| − | Class/mechanism: Gonadotropin-releasing hormone (GnRH) receptor antagonist. Reversibly binds to pituitary GnRH receptors, reducing the release of luteinizing hormone (LH) and follicle stimulation hormone (FSH), resulting in rapid androgen deprivation/decreased testosterone levels. There is no initial testosterone surge/flare with degarelix, in contrast to GnRH agonists.<ref name="insert">[http://www.firmagon.us/ | + | Class/mechanism: Gonadotropin-releasing hormone (GnRH) receptor antagonist. Reversibly binds to pituitary GnRH receptors, reducing the release of luteinizing hormone (LH) and follicle stimulation hormone (FSH), resulting in rapid androgen deprivation/decreased testosterone levels. There is no initial testosterone surge/flare with degarelix, in contrast to GnRH agonists.<ref name="insert">[http://www.firmagon.us/full_pi.pdf Degarelix (Firmagon) package insert]</ref><ref>[[Media:Degarelix.pdf | Degarelix (Firmagon) package insert (locally hosted backup)]]</ref> |
<br>Route: SC | <br>Route: SC | ||
<br>Extravasation: n/a | <br>Extravasation: n/a | ||
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | ||
| + | |||
| + | ==Diseases for which it is used== | ||
| + | *[[Prostate cancer]] | ||
==Patient drug information== | ==Patient drug information== | ||
| + | *[http://www.firmagon.us/full_pi.pdf#page=17 Degarelix (Firmagon) package insert pages 17-19]<ref name="insert"></ref> | ||
*[http://www.uptodate.com/contents/degarelix-patient-drug-information Degarelix (Firmagon) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/degarelix-patient-drug-information Degarelix (Firmagon) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/degarelix-patient-drug-information Degarelix (Firmagon) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/degarelix-patient-drug-information Degarelix (Firmagon) patient drug information (UpToDate)]</ref> | ||
==References== | ==References== | ||
<references/> | <references/> | ||
| + | |||
| + | [[Category:Drug index]] | ||
| + | [[Category:GnRH antagonists]] | ||
| + | [[Category:Prostate cancer medications]] | ||
Revision as of 19:28, 14 October 2012
Also known as degarelix acetate or FE200486.
General information
Class/mechanism: Gonadotropin-releasing hormone (GnRH) receptor antagonist. Reversibly binds to pituitary GnRH receptors, reducing the release of luteinizing hormone (LH) and follicle stimulation hormone (FSH), resulting in rapid androgen deprivation/decreased testosterone levels. There is no initial testosterone surge/flare with degarelix, in contrast to GnRH agonists.[1][2]
Route: SC
Extravasation: n/a
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
Patient drug information
- Degarelix (Firmagon) package insert pages 17-19[1]
- Degarelix (Firmagon) patient drug information (UpToDate)[3]