Difference between revisions of "Linsitinib (OSI-906)"
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Warner-admin (talk | contribs) m (Text replacement - "(NCT[0-9]{8})" to "[https://clinicaltrials.gov/ct2/show/$1 Clinical Trial Registry]") |
Warner-admin (talk | contribs) m (Text replacement - "'''dosing details in manuscript have been reviewed'''" to "'''dosing details in manuscript have been reviewed by our editors'''") |
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==Preliminary data== | ==Preliminary data== | ||
===[[Gastrointestinal stromal tumor]]=== | ===[[Gastrointestinal stromal tumor]]=== | ||
− | #'''SARC 022:''' Von Mehren M, George S, Heinrich M, Schuetze S, Yap J, Yu J, Abbott A, Litwin S, Crowley J, Belinsky M, Janeway K, Hornick J, Flieder D, Chugh R, Rink L, Van den Abbeele A; Linsitinib (OSI-906) for the Treatment of Adult and Pediatric Wild-Type Gastrointestinal Stromal Tumors, a SARC Phase II Study. Clin Cancer Res. 2020 April; 15;26(8):1837-1845. Epub 2019 Dec 2. [https://clincancerres.aacrjournals.org/content/26/8/1837.long link to original article] [https://www.ncbi.nlm.nih.gov/pmc/articles/pmc7856429/ link to PMC article] ''' | + | #'''SARC 022:''' Von Mehren M, George S, Heinrich M, Schuetze S, Yap J, Yu J, Abbott A, Litwin S, Crowley J, Belinsky M, Janeway K, Hornick J, Flieder D, Chugh R, Rink L, Van den Abbeele A; Linsitinib (OSI-906) for the Treatment of Adult and Pediatric Wild-Type Gastrointestinal Stromal Tumors, a SARC Phase II Study. Clin Cancer Res. 2020 April; 15;26(8):1837-1845. Epub 2019 Dec 2. [https://clincancerres.aacrjournals.org/content/26/8/1837.long link to original article] [https://www.ncbi.nlm.nih.gov/pmc/articles/pmc7856429/ link to PMC article] '''dosing details in manuscript have been reviewed by our editors''' [https://pubmed.ncbi.nlm.nih.gov/31792037/ PubMed] [https://clinicaltrials.gov/study/NCT01560260 NCT01560260] |
==Also known as== | ==Also known as== |
Latest revision as of 12:20, 15 July 2024
Mechanism of action
An orally bioavailable small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with potential antineoplastic activity. Linsitinib selectively inhibits IGF-1R, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis.
Preliminary data
Gastrointestinal stromal tumor
- SARC 022: Von Mehren M, George S, Heinrich M, Schuetze S, Yap J, Yu J, Abbott A, Litwin S, Crowley J, Belinsky M, Janeway K, Hornick J, Flieder D, Chugh R, Rink L, Van den Abbeele A; Linsitinib (OSI-906) for the Treatment of Adult and Pediatric Wild-Type Gastrointestinal Stromal Tumors, a SARC Phase II Study. Clin Cancer Res. 2020 April; 15;26(8):1837-1845. Epub 2019 Dec 2. link to original article link to PMC article dosing details in manuscript have been reviewed by our editors PubMed NCT01560260
Also known as
- Code name: OSI-906