Difference between revisions of "Refametinib (BAY-869766)"
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==Also known as== | ==Also known as== | ||
| − | *'''Code name:''' BAY 869766 | + | *'''Code name:''' BAY-869766 |
[[Category:Drugs]] | [[Category:Drugs]] | ||
Latest revision as of 12:43, 27 July 2023
Mechanism of action
From the NCI Drug Dictionary: An orally bioavailable selective MEK inhibitor with potential antineoplastic activity. Refametinib specifically inhibits mitogen-activated protein kinase kinase 1 (MAP2K1 or MAPK/ERK kinase 1), resulting in inhibition of growth factor-mediated cell signaling and tumor cell proliferation.
Preliminary data
Hepatocellular carcinoma
- Lim HY, Merle P, Weiss KH, Yau T, Ross P, Mazzaferro V, Blanc JF, Ma YT, Yen CJ, Kocsis J, Choo SP, Sukeepaisarnjaroen W, Gérolami R, Dufour JF, Gane EJ, Ryoo BY, Peck-Radosavljevic M, Dao T, Yeo W, Lamlertthon W, Thongsawat S, Teufel M, Roth K, Reis D, Childs BH, Krissel H, Llovet JM. Phase II Studies with Refametinib or Refametinib plus Sorafenib in Patients with RAS-Mutated Hepatocellular Carcinoma. Clin Cancer Res. 2018 Oct 1;24(19):4650-4661. Epub 2018 Jun 27. link to original article PubMed
Also known as
- Code name: BAY-869766