Difference between revisions of "Finasteride (Proscar)"
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==General information== | ==General information== | ||
| − | Class/mechanism: <ref name="insert">[http://www.merck.com/product/usa/pi_circulars/p/proscar/proscar_pi.pdf Finasteride (Proscar) package insert]</ref><ref>[ | + | Class/mechanism: 5 alpha-reductase inhibitor; inhibits conversion of testosterone to dihydrotestosterone (DHT). Specifically and competitively inhibits Type II 5α-reductase by forming a stable enzyme-drug complex.<ref name="insert">[http://www.merck.com/product/usa/pi_circulars/p/proscar/proscar_pi.pdf Finasteride (Proscar) package insert]</ref><ref>[https://hemonc.org/docs/packageinsert/finasteride.pdf Finasteride (Proscar) package insert (locally hosted backup)]</ref> |
| − | <br>Route: | + | <br>Route: PO |
| − | <br>Extravasation: | + | <br>Extravasation: n/a |
| − | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. | + | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [https://online.lexi.com/lco/action/login UpToDate Lexidrug], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> |
==Patient drug information== | ==Patient drug information== | ||
*[http://www.uptodate.com/contents/finasteride-patient-drug-information Finasteride (Proscar) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/finasteride-patient-drug-information Finasteride (Proscar) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/finasteride-patient-drug-information Finasteride (Proscar) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/finasteride-patient-drug-information Finasteride (Proscar) patient drug information (UpToDate)]</ref> | ||
| + | |||
| + | ==History of changes in FDA indication== | ||
| + | ''No antineoplastic label, at this time.'' | ||
| + | *1992-06-19: Initial approval | ||
| + | |||
| + | ==Also known as== | ||
| + | *'''Brand name:''' Proscar | ||
==References== | ==References== | ||
<references/> | <references/> | ||
| + | |||
| + | [[Category:Drugs]] | ||
| + | [[Category:Oral medications]] | ||
| + | |||
| + | [[Category:Antiandrogens]] | ||
| + | [[Category:5 alpha-reductase inhibitors]] | ||
| + | |||
| + | [[Category:FDA approved in 1992]] | ||
Latest revision as of 01:00, 27 June 2024
General information
Class/mechanism: 5 alpha-reductase inhibitor; inhibits conversion of testosterone to dihydrotestosterone (DHT). Specifically and competitively inhibits Type II 5α-reductase by forming a stable enzyme-drug complex.[1][2]
Route: PO
Extravasation: n/a
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, UpToDate Lexidrug, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Patient drug information
History of changes in FDA indication
No antineoplastic label, at this time.
- 1992-06-19: Initial approval
Also known as
- Brand name: Proscar