Difference between revisions of "Thrombocytosis"
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==Definition== | ==Definition== | ||
| − | Platelet count greater than or equal to 450 | + | Platelet count greater than or equal to 450 x 10<sup>9</sup>/L (''local reference ranges may vary'').<ref>Elisa Rumi and Mario Cazzola. [https://doi.org/10.1182/blood-2016-05-643346 How I treat essential thrombocythemia.] Blood 2016 128:2403-2414. [https://pubmed.ncbi.nlm.nih.gov/27561316/ PubMed]</ref> |
==Initial evaluation== | ==Initial evaluation== | ||
| Line 12: | Line 12: | ||
*MPL exon 10 mutations | *MPL exon 10 mutations | ||
*[[Peripheral smear findings|Peripheral smear]] | *[[Peripheral smear findings|Peripheral smear]] | ||
| − | *Clinical history (e.g. recent surgery or other reasons for reactive thrombocytosis), lifestyle factors | + | *Splenectomy |
| + | *Clinical history (e.g. recent surgery or other reasons for reactive thrombocytosis), lifestyle factors | ||
==References== | ==References== | ||
Latest revision as of 20:13, 27 June 2024
Definition
Platelet count greater than or equal to 450 x 109/L (local reference ranges may vary).[1]
Initial evaluation
May consist of:
- CBC with differential
- Iron, total iron binding capacity (TIBC), ferritin
- JAK2 V617F mutation
- CALR exon 9 indels
- MPL exon 10 mutations
- Peripheral smear
- Splenectomy
- Clinical history (e.g. recent surgery or other reasons for reactive thrombocytosis), lifestyle factors
References
- ↑ Elisa Rumi and Mario Cazzola. How I treat essential thrombocythemia. Blood 2016 128:2403-2414. PubMed