Difference between revisions of "Dinaciclib (SCH-727965)"
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Warner-admin (talk | contribs) m (Text replacement - "Chronic lymphocytic leukemia (CLL) and Small lymphocytic lymphoma (SLL)" to "Chronic lymphocytic leukemia (CLL/SLL)") |
Warner-admin (talk | contribs) m (Warner-admin moved page Dinaciclib (SCH 727965) to Dinaciclib (SCH-727965) without leaving a redirect) |
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==Preliminary data== | ==Preliminary data== | ||
− | ===[[Chronic lymphocytic leukemia | + | ===[[Chronic lymphocytic leukemia]]=== |
− | # Flynn J, Jones J, Johnson AJ, Andritsos L, Maddocks K, Jaglowski S, Hessler J, Grever MR, Im E, Zhou H, Zhu Y, Zhang D, Small K, Bannerji R, Byrd JC. Dinaciclib is a novel cyclin-dependent kinase inhibitor with significant clinical activity in relapsed and refractory chronic lymphocytic leukemia. Leukemia. 2015 Jul;29(7):1524-9. Epub 2015 Feb 24. [ | + | # Flynn J, Jones J, Johnson AJ, Andritsos L, Maddocks K, Jaglowski S, Hessler J, Grever MR, Im E, Zhou H, Zhu Y, Zhang D, Small K, Bannerji R, Byrd JC. Dinaciclib is a novel cyclin-dependent kinase inhibitor with significant clinical activity in relapsed and refractory chronic lymphocytic leukemia. Leukemia. 2015 Jul;29(7):1524-9. Epub 2015 Feb 24. [https://doi.org/10.1038/leu.2015.31 link to original article] [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551390/ link to PMC article] [https://pubmed.ncbi.nlm.nih.gov/25708835/ PubMed] |
+ | # Ghia P, Scarfò L, Perez S, Pathiraja K, Derosier M, Small K, McCrary Sisk C, Patton N. Efficacy and safety of dinaciclib vs ofatumumab in patients with relapsed/refractory chronic lymphocytic leukemia. Blood. 2017 Mar 30;129(13):1876-1878. Epub 2017 Jan 26. [http://www.bloodjournal.org/content/129/13/1876.long link to original article] [https://pubmed.ncbi.nlm.nih.gov/28126927/ PubMed] | ||
===[[Multiple myeloma]]=== | ===[[Multiple myeloma]]=== | ||
− | # Kumar SK, LaPlant B, Chng WJ, Zonder J, Callander N, Fonseca R, Fruth B, Roy V, Erlichman C, Stewart AK. Dinaciclib, a novel CDK inhibitor, demonstrates encouraging single agent activity in patients with relapsed multiple myeloma. Blood. 2015 Jan 15;125(3):443-8. Epub 2014 Nov 13. [http://www.bloodjournal.org/content/125/3/443 link to original article] [https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25395429/ link to PMC article] [https:// | + | # Kumar SK, LaPlant B, Chng WJ, Zonder J, Callander N, Fonseca R, Fruth B, Roy V, Erlichman C, Stewart AK. Dinaciclib, a novel CDK inhibitor, demonstrates encouraging single agent activity in patients with relapsed multiple myeloma. Blood. 2015 Jan 15;125(3):443-8. Epub 2014 Nov 13. [http://www.bloodjournal.org/content/125/3/443 link to original article] [https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25395429/ link to PMC article] [https://pubmed.ncbi.nlm.nih.gov/25395429/ PubMed] |
− | [[Category: | + | ==Also known as== |
+ | *'''Code names:''' MK-7965, SCH-727965 | ||
+ | |||
+ | [[Category:Drugs]] | ||
[[Category:Intravenous medications]] | [[Category:Intravenous medications]] | ||
− | |||
[[Category:CDK inhibitors]] | [[Category:CDK inhibitors]] | ||
− | [[Category:Investigational]] | + | [[Category:Chronic lymphocytic leukemia medications (investigational)]] |
+ | [[Category:Multiple myeloma medications (investigational)]] | ||
+ | |||
+ | [[Category:Investigational drugs]] |
Latest revision as of 00:28, 29 July 2023
Mechanism of action
A cyclin dependent kinase inhibitor that selectively inhibits cyclin dependent kinases CDK1, CDK2, CDK5, CDK9, and CDK12.
Preliminary data
Chronic lymphocytic leukemia
- Flynn J, Jones J, Johnson AJ, Andritsos L, Maddocks K, Jaglowski S, Hessler J, Grever MR, Im E, Zhou H, Zhu Y, Zhang D, Small K, Bannerji R, Byrd JC. Dinaciclib is a novel cyclin-dependent kinase inhibitor with significant clinical activity in relapsed and refractory chronic lymphocytic leukemia. Leukemia. 2015 Jul;29(7):1524-9. Epub 2015 Feb 24. link to original article link to PMC article PubMed
- Ghia P, Scarfò L, Perez S, Pathiraja K, Derosier M, Small K, McCrary Sisk C, Patton N. Efficacy and safety of dinaciclib vs ofatumumab in patients with relapsed/refractory chronic lymphocytic leukemia. Blood. 2017 Mar 30;129(13):1876-1878. Epub 2017 Jan 26. link to original article PubMed
Multiple myeloma
- Kumar SK, LaPlant B, Chng WJ, Zonder J, Callander N, Fonseca R, Fruth B, Roy V, Erlichman C, Stewart AK. Dinaciclib, a novel CDK inhibitor, demonstrates encouraging single agent activity in patients with relapsed multiple myeloma. Blood. 2015 Jan 15;125(3):443-8. Epub 2014 Nov 13. link to original article link to PMC article PubMed
Also known as
- Code names: MK-7965, SCH-727965