Difference between revisions of "Example orders for 5-FU & high-dose Leucovorin (Roswell Park regimen - HDLV) in colon cancer"
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Warner-admin (talk | contribs) m (Warner-admin moved page Example orders for 5-FU & high-dose Leucovorin (Roswell Park regimen/HDLV) in colon cancer to Example orders for 5-FU & high-dose Leucovorin (Roswell Park regimen - HDLV) in colon cancer without leaving a redirect: Reser...) |
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| + | Remember that example order sets that may contain additional information about supportive medications, suggestions for monitoring, hydration, and pre-treatment screening information for chemotherapy regimens are purely anecdotal, provided only as examples of what some other providers may be using, and are typically not based on references in the primary literature. | ||
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==5-FU & high-dose Leucovorin (Roswell Park regimen/HDLV)== | ==5-FU & high-dose Leucovorin (Roswell Park regimen/HDLV)== | ||
| − | Original | + | Original references may be found at [[Colon_cancer#Fluorouracil_monotherapy_.26_Folinic_acid_.28Leucovorin.29|5-FU & high-dose Leucovorin (Roswell Park regimen/HDLV) (adjuvant)]] & [[Colon_cancer#Fluorouracil_monotherapy_.26_Folinic_acid_.28Leucovorin.29_2|5-FU & high-dose Leucovorin (Roswell Park regimen/HDLV) (metastatic)]] |
===Example regimen #1=== | ===Example regimen #1=== | ||
| − | *[[Folinic acid (Leucovorin)]] 500 mg/ | + | *[[Folinic acid (Leucovorin)]] 500 mg/m<sup>2</sup> IV over 2 hours on days 1, 8, 15, 22, 29, 36, given first |
| − | *[[Fluorouracil (5-FU)]] 500 mg/ | + | *[[Fluorouracil (5-FU)]] 500 mg/m<sup>2</sup> IV push on days 1, 8, 15, 22, 29, 36, 1 hour after start of leucovorin |
'''8-week cycles x 3-4 cycles for adjuvant therapy; in metastatic settings, given until progression of disease or unacceptable toxicity''' | '''8-week cycles x 3-4 cycles for adjuvant therapy; in metastatic settings, given until progression of disease or unacceptable toxicity''' | ||
| − | Supportive medications | + | ====Supportive medications==== |
| − | *Prochlorperazine (Compazine) 10 mg PO 30 minutes prior to chemotherapy | + | *Prochlorperazine (Compazine) 10 mg PO once; 30 minutes prior to chemotherapy |
*Ondansetron (Zofran) 8 mg IV prn nausea | *Ondansetron (Zofran) 8 mg IV prn nausea | ||
*[[Dexamethasone (Decadron)]] 10 mg IV prn nausea | *[[Dexamethasone (Decadron)]] 10 mg IV prn nausea | ||
| Line 23: | Line 25: | ||
Monitoring: | Monitoring: | ||
*Hold if patient has significant diarrhea/mucositis, ANC <1000, or platelets <100 and notify physician. | *Hold if patient has significant diarrhea/mucositis, ANC <1000, or platelets <100 and notify physician. | ||
| + | |||
| + | [[Category:Example chemotherapy order sets]] | ||
Latest revision as of 18:57, 23 November 2019
Remember that example order sets that may contain additional information about supportive medications, suggestions for monitoring, hydration, and pre-treatment screening information for chemotherapy regimens are purely anecdotal, provided only as examples of what some other providers may be using, and are typically not based on references in the primary literature.
5-FU & high-dose Leucovorin (Roswell Park regimen/HDLV)
Original references may be found at 5-FU & high-dose Leucovorin (Roswell Park regimen/HDLV) (adjuvant) & 5-FU & high-dose Leucovorin (Roswell Park regimen/HDLV) (metastatic)
Example regimen #1
- Folinic acid (Leucovorin) 500 mg/m2 IV over 2 hours on days 1, 8, 15, 22, 29, 36, given first
- Fluorouracil (5-FU) 500 mg/m2 IV push on days 1, 8, 15, 22, 29, 36, 1 hour after start of leucovorin
8-week cycles x 3-4 cycles for adjuvant therapy; in metastatic settings, given until progression of disease or unacceptable toxicity
Supportive medications
- Prochlorperazine (Compazine) 10 mg PO once; 30 minutes prior to chemotherapy
- Ondansetron (Zofran) 8 mg IV prn nausea
- Dexamethasone (Decadron) 10 mg IV prn nausea
Hydration:
- 500 ml NS at KVO rate as running IV for chemotherapy infusion. Give up to 500 ml NS.
Monitoring:
- Hold if patient has significant diarrhea/mucositis, ANC <1000, or platelets <100 and notify physician.