Difference between revisions of "Protamine sulfate (USP)"
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==General information== | ==General information== | ||
| − | Class/mechanism: Heparin antagonist; protamine sulfate is a weak anticoagulant that forms a stable salt with heparin, after which the anticoagulant effect of both drugs is negated.<ref name="insert">[http://editor.apppharma.com/PIs/Protamine_Inj_45848E_Jan_08.pdf Protamine sulfate package insert]</ref><ref>[ | + | Class/mechanism: Heparin antagonist; protamine sulfate is a weak anticoagulant that forms a stable salt with heparin, after which the anticoagulant effect of both drugs is negated.<ref name="insert">[http://editor.apppharma.com/PIs/Protamine_Inj_45848E_Jan_08.pdf Protamine sulfate package insert]</ref><ref>[https://hemonc.org/docs/packageinsert/protamine.pdf Protamine sulfate package insert (locally hosted backup)]</ref><ref>[https://wiki.umms.med.umich.edu/download/attachments/90738943/UMHS+Anticoagulation_Reversal.pdf University of Michigan Health System Anticoagulation Reversal]</ref> |
<br>Route: IV | <br>Route: IV | ||
<br>Extravasation: no information | <br>Extravasation: no information | ||
| − | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. | + | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> |
| + | |||
| + | ==Diseases for which it is used== | ||
| + | *[[Bleeding with anticoagulation]] | ||
==Patient drug information== | ==Patient drug information== | ||
*[http://www.uptodate.com/contents/protamine-sulfate-patient-drug-information Protamine sulfate patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/protamine-sulfate-patient-drug-information Protamine sulfate patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/protamine-sulfate-patient-drug-information Protamine sulfate patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/protamine-sulfate-patient-drug-information Protamine sulfate patient drug information (UpToDate)]</ref> | ||
| + | ==Also known as== | ||
| + | *'''Generic name:''' USP | ||
==References== | ==References== | ||
<references/> | <references/> | ||
| + | |||
| + | [[Category:Drugs]] | ||
| + | [[Category:Intravenous medications]] | ||
| + | |||
| + | [[Category:Heparin antagonist]] | ||
| + | [[Category:Hemostasis medications]] | ||
| + | |||
| + | [[Category:FDA approved in 1969]] | ||
Latest revision as of 19:32, 23 June 2024
General information
Class/mechanism: Heparin antagonist; protamine sulfate is a weak anticoagulant that forms a stable salt with heparin, after which the anticoagulant effect of both drugs is negated.[1][2][3]
Route: IV
Extravasation: no information
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
Patient drug information
Also known as
- Generic name: USP