Difference between revisions of "Paclitaxel (Taxol)"
(Created page with "==General information== Class/mechanism: <ref name="insert">[http://packageinserts.bms.com/pi/pi_taxol.pdf Paclitaxel (Taxol) package insert]</ref><ref>[http://hemonc.org/docs/pa...") |
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| + | Also known as Onxal. | ||
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==General information== | ==General information== | ||
| − | Class/mechanism: <ref name="insert">[http://packageinserts.bms.com/pi/pi_taxol.pdf Paclitaxel (Taxol) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/paclitaxel.pdf Paclitaxel (Taxol) package insert (locally hosted backup)]</ref> | + | Class/mechanism: Taxane, promotes assembly of microtubules, stablizes microtubules, preventing depolymerization. Paclitaxel interferes with the normal dynamic reorganization of microtubules that is necessary for regular interphase/mitosis processes. It also leads to creation of abnormal bundles of microtubules. Paclitaxel is highly lipophilic/insoluble in water and needs to be dissolved in Cremophor EL (polyoxyethylated castor oil), which may cause hypersensitivity infusion reactions.<ref name="insert">[http://packageinserts.bms.com/pi/pi_taxol.pdf Paclitaxel (Taxol) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/paclitaxel.pdf Paclitaxel (Taxol) package insert (locally hosted backup)]</ref> |
| − | <br>Route: | + | <br>Route: IV |
| − | <br>Extravasation: | + | <br>Extravasation: [[irritant]] (usually), [[vesicant]] (rare) |
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the package insert<ref name="insert"></ref>. | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the package insert<ref name="insert"></ref>. | ||
==Patient drug information== | ==Patient drug information== | ||
| + | *[http://packageinserts.bms.com/pi/pi_taxol.pdf#page=50 Paclitaxel (Taxol) package insert PDF pages 50-53]<ref name="insert"></ref> | ||
*[http://chemocare.com/bio/paclitaxel.asp Paclitaxel (Taxol) patient drug information (Chemocare)]<ref>[http://chemocare.com/bio/paclitaxel.asp Paclitaxel (Taxol) patient drug information (Chemocare)]</ref> | *[http://chemocare.com/bio/paclitaxel.asp Paclitaxel (Taxol) patient drug information (Chemocare)]<ref>[http://chemocare.com/bio/paclitaxel.asp Paclitaxel (Taxol) patient drug information (Chemocare)]</ref> | ||
*[http://www.uptodate.com/contents/paclitaxel-patient-drug-information Paclitaxel (Taxol) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/paclitaxel-patient-drug-information Paclitaxel (Taxol) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/paclitaxel-patient-drug-information Paclitaxel (Taxol) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/paclitaxel-patient-drug-information Paclitaxel (Taxol) patient drug information (UpToDate)]</ref> | ||
Revision as of 22:07, 23 February 2012
Also known as Onxal.
General information
Class/mechanism: Taxane, promotes assembly of microtubules, stablizes microtubules, preventing depolymerization. Paclitaxel interferes with the normal dynamic reorganization of microtubules that is necessary for regular interphase/mitosis processes. It also leads to creation of abnormal bundles of microtubules. Paclitaxel is highly lipophilic/insoluble in water and needs to be dissolved in Cremophor EL (polyoxyethylated castor oil), which may cause hypersensitivity infusion reactions.[1][2]
Route: IV
Extravasation: irritant (usually), vesicant (rare)
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the package insert[1].
Patient drug information
- Paclitaxel (Taxol) package insert PDF pages 50-53[1]
- Paclitaxel (Taxol) patient drug information (Chemocare)[3]
- Paclitaxel (Taxol) patient drug information (UpToDate)[4]