Difference between revisions of "Methotrexate (MTX)"
(Created page with "==General information== Class/mechanism: <ref name="insert">[http://www.rheumatrex.info/pdf/RheumatrexPackageInsert.pdf Methotrexate (MTX) package insert]</ref><ref>[http://hemon...") |
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| + | Also known as Amethopterin, Rheumatrex, or Trexall. | ||
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==General information== | ==General information== | ||
| − | Class/mechanism: <ref name="insert">[http://www.rheumatrex.info/pdf/RheumatrexPackageInsert.pdf Methotrexate (MTX) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/methotrexate.pdf Methotrexate (MTX) package insert (locally hosted backup)]</ref> | + | Class/mechanism: Folate analog, antimetabolite, interferes with DNA synthesis. Methotrexate inhibits dihydrofolic acid reductase, which catalyzes reactions that produce tetrahydrofolates, which are used in purine nucleotide and thymidylate synthesis.<ref name="insert">[http://www.rheumatrex.info/pdf/RheumatrexPackageInsert.pdf Methotrexate (MTX) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/methotrexate.pdf Methotrexate (MTX) package insert (locally hosted backup)]</ref> |
| − | <br>Route: | + | <br>Route: IV, PO, IM, IT, intraarterial |
| − | <br>Extravasation: | + | <br>Extravasation: no information |
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the package insert<ref name="insert"></ref>. | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the package insert<ref name="insert"></ref>. | ||
Revision as of 20:14, 23 February 2012
Also known as Amethopterin, Rheumatrex, or Trexall.
General information
Class/mechanism: Folate analog, antimetabolite, interferes with DNA synthesis. Methotrexate inhibits dihydrofolic acid reductase, which catalyzes reactions that produce tetrahydrofolates, which are used in purine nucleotide and thymidylate synthesis.[1][2]
Route: IV, PO, IM, IT, intraarterial
Extravasation: no information
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the package insert[1].
Patient drug information
- Methotrexate (MTX) patient drug information (Chemocare)[3]
- Methotrexate (MTX) patient drug information (UpToDate)[4]