Difference between revisions of "Fluorouracil (5-FU)"
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==General information== | ==General information== | ||
| − | Class/mechanism: Pyrimidine analog, antimetabolite, inhibitor of thymidylate synthase. Metabolized to 5-fluoro-2'-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP). FdUMP inhibits DNA synthesis by binding to thymidylate synthase and inhibiting production of thymidylate; FUTP interferes with RNA processing when it is mistakenly incorporated in place of uridine triphosphate (UTP).<ref name="insert">[http://patient.cancerconsultants.com/druginserts/Fluorouracil.pdf Fluorouracil (5-FU) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/fluorouracil.pdf Fluorouracil (5-FU) package insert (locally hosted backup)]</ref> [http://en.wikipedia.org/wiki/Fluorouracil#Interactive_pathway_map 5-FU pathway]. | + | Class/mechanism: Pyrimidine analog, antimetabolite, inhibitor of thymidylate synthase. Metabolized to 5-fluoro-2'-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP). FdUMP inhibits DNA synthesis by binding to thymidylate synthase and inhibiting production of thymidylate; FUTP interferes with RNA processing when it is mistakenly incorporated in place of uridine triphosphate (UTP).<ref name="insert">[http://patient.cancerconsultants.com/druginserts/Fluorouracil.pdf Fluorouracil (5-FU) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/fluorouracil.pdf Fluorouracil (5-FU) package insert (locally hosted backup)]</ref> <ref>[http://en.wikipedia.org/wiki/Fluorouracil#Interactive_pathway_map 5-FU pathway]</ref>. |
<br>Route: IV | <br>Route: IV | ||
<br>Extravasation: [[irritant]] | <br>Extravasation: [[irritant]] | ||
Revision as of 22:30, 22 February 2012
Also known as Adrucil.
General information
Class/mechanism: Pyrimidine analog, antimetabolite, inhibitor of thymidylate synthase. Metabolized to 5-fluoro-2'-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP). FdUMP inhibits DNA synthesis by binding to thymidylate synthase and inhibiting production of thymidylate; FUTP interferes with RNA processing when it is mistakenly incorporated in place of uridine triphosphate (UTP).[1][2] [3].
Route: IV
Extravasation: irritant
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the package insert[1].
Patient drug information
- Fluorouracil (5-FU) patient drug information (Chemocare)[4]
- Fluorouracil (5-FU) patient drug information (UpToDate)[5]