Difference between revisions of "Leucovorin (Folinic acid)"
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==General information== | ==General information== | ||
| − | Class/mechanism: Folic acid analog; counteracts the effects of folic acid antagonists such as methotrexate, which acts by inhibiting dihydrofolate reductase.<ref name="insert">[http://patient.cancerconsultants.com/druginserts/Leucovorin_inj.pdf Folinic acid (Leucovorin) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/folinicacid.pdf Folinic acid (Leucovorin) package insert (locally hosted backup)]</ref> | + | Class/mechanism: Folic acid analog; counteracts the effects of folic acid antagonists such as methotrexate, which acts by inhibiting dihydrofolate reductase. Enhances the activity of [[Fluorouracil (5-FU)]] by inhibiting thymidylate synthase.<ref name="insert">[http://patient.cancerconsultants.com/druginserts/Leucovorin_inj.pdf Folinic acid (Leucovorin) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/folinicacid.pdf Folinic acid (Leucovorin) package insert (locally hosted backup)]</ref> |
<br>Route: PO, IM, IV | <br>Route: PO, IM, IV | ||
<br>Extravasation: no information | <br>Extravasation: no information | ||
Revision as of 00:07, 22 February 2012
General information
Class/mechanism: Folic acid analog; counteracts the effects of folic acid antagonists such as methotrexate, which acts by inhibiting dihydrofolate reductase. Enhances the activity of Fluorouracil (5-FU) by inhibiting thymidylate synthase.[1][2]
Route: PO, IM, IV
Extravasation: no information
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the package insert[1].
Patient drug information
- Folinic acid (Leucovorin) patient drug information (Chemocare)[3]
- Folinic acid (Leucovorin) patient drug information (UpToDate)[4]