Difference between revisions of "Belotecan (Camptobell)"
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==General information== | ==General information== | ||
− | Class/mechanism from the [https://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=537355 NCI Drug Dictionary]: The hydrochloride salt of the semi-synthetic camptothecin | + | Class/mechanism from the [https://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=537355 NCI Drug Dictionary]: The hydrochloride salt of the semi-synthetic camptothecin analog belotecan with potential antitumor activity. Belotecan binds to and inhibits the activity of topoisomerase I, stabilizing the cleavable complex of topoisomerase I-DNA, which inhibits the religation of single-stranded DNA breaks generated by topoisomerase I; lethal double-stranded DNA breaks occur when the topoisomerase I-DNA complex is encountered by the DNA replication machinery, DNA replication is disrupted, and the tumor cell undergoes apoptosis. |
<br>Route: IV | <br>Route: IV | ||
<br>Extravasation: [[irritant]] | <br>Extravasation: [[irritant]] | ||
− | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias | + | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias or the prescribing information. |
==Diseases for which it is used== | ==Diseases for which it is used== | ||
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*'''Brand name:''' Camptobell | *'''Brand name:''' Camptobell | ||
− | [[Category: | + | [[Category:Drugs]] |
[[Category:Intravenous medications]] | [[Category:Intravenous medications]] | ||
− | [[Category:Irritant | + | [[Category:Irritant]] |
− | [[Category:Topoisomerase inhibitors]] | + | [[Category:Topoisomerase I inhibitors]] |
[[Category:Ovarian cancer medications]] | [[Category:Ovarian cancer medications]] |
Latest revision as of 01:04, 29 June 2024
General information
Class/mechanism from the NCI Drug Dictionary: The hydrochloride salt of the semi-synthetic camptothecin analog belotecan with potential antitumor activity. Belotecan binds to and inhibits the activity of topoisomerase I, stabilizing the cleavable complex of topoisomerase I-DNA, which inhibits the religation of single-stranded DNA breaks generated by topoisomerase I; lethal double-stranded DNA breaks occur when the topoisomerase I-DNA complex is encountered by the DNA replication machinery, DNA replication is disrupted, and the tumor cell undergoes apoptosis.
Route: IV
Extravasation: irritant
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias or the prescribing information.
Diseases for which it is used
Also known as
- Code name: CKD-602
- Generic name: belotecan hydrochloride
- Brand name: Camptobell