Difference between revisions of "Histrelin (Vantas)"
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| − | = | + | ==General information== |
| − | + | Class/mechanism: LH-RH agonist. Histrelin acetate inhibits gonadotropin secretion by desensitizing responsiveness of the pituitary gonadotropin which, in turn, causes a reduction in testicular steroidogenesis.<ref name="insert">[https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/021732s015lbl.pdf Histrelin (Vantas) package insert]</ref><ref>[[:File:Histrelin.pdf | Histrelin (Vantas) package insert (locally hosted backup)]]</ref><ref>[http://www.vantasimplant.com/ Vantas implant manufacturer's website]</ref> | |
| + | <br>Route: SC | ||
| + | <br>Extravasation: no information | ||
| − | =Diseases for which it is used= | + | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias or the prescribing information.<ref name="insert"></ref> |
| + | |||
| + | ==Diseases for which it is used== | ||
*[[Prostate cancer]] | *[[Prostate cancer]] | ||
| − | =History of changes in FDA indication= | + | ==History of changes in FDA indication== |
| − | *10 | + | *2004-10-12: Initial approval in the palliative treatment of advanced [[prostate cancer]]. ''(Based on Schlegel 2006)'' |
| + | ==History of changes in Health Canada indication== | ||
| + | *2006-03-10: Initial notice of compliance (unclear details) | ||
| + | ==Patient drug information== | ||
| + | *[https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/021732s015lbl.pdf Histrelin (Vantas) package insert]<ref name="insert"></ref> | ||
| + | |||
| + | ==Also known as== | ||
| + | *'''Generic name:''' histrelin acetate | ||
| + | *'''Brand names:''' Supprelin, Vantas | ||
| + | |||
| + | ==References== | ||
| + | <references/> | ||
| − | [[Category: | + | [[Category:Drugs]] |
| + | [[Category:Subcutaneous medications]] | ||
| − | [[Category: | + | [[Category:GnRH agonists]] |
| − | |||
[[Category:Prostate cancer medications]] | [[Category:Prostate cancer medications]] | ||
| − | [[Category: | + | [[Category:FDA approved in 2004]] |
| + | [[Category:Health Canada approved in 2006]] | ||
Latest revision as of 01:03, 29 June 2024
General information
Class/mechanism: LH-RH agonist. Histrelin acetate inhibits gonadotropin secretion by desensitizing responsiveness of the pituitary gonadotropin which, in turn, causes a reduction in testicular steroidogenesis.[1][2][3]
Route: SC
Extravasation: no information
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias or the prescribing information.[1]
Diseases for which it is used
History of changes in FDA indication
- 2004-10-12: Initial approval in the palliative treatment of advanced prostate cancer. (Based on Schlegel 2006)
History of changes in Health Canada indication
- 2006-03-10: Initial notice of compliance (unclear details)
Patient drug information
Also known as
- Generic name: histrelin acetate
- Brand names: Supprelin, Vantas