Difference between revisions of "Flutamide (Eulexin)"
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==General information== | ==General information== | ||
| − | Class/mechanism: Antiandrogen; non-steroidal. Inhibits androgen uptake and/or inhibits nuclear binding of androgen in target tissues.<ref name="insert">[http://www.merckfrosst.ca/assets/en/pdf/products/Euflex-PM_E.pdf Flutamide (Eulexin) package insert]</ref><ref>[ | + | Class/mechanism: Antiandrogen; non-steroidal. Inhibits androgen uptake and/or inhibits nuclear binding of androgen in target tissues.<ref name="insert">[http://www.merckfrosst.ca/assets/en/pdf/products/Euflex-PM_E.pdf Flutamide (Eulexin) package insert]</ref><ref>[https://hemonc.org/docs/packageinsert/flutamide.pdf Flutamide (Eulexin) package insert (locally hosted backup)]</ref> |
<br>Route: PO | <br>Route: PO | ||
<br>Extravasation: n/a | <br>Extravasation: n/a | ||
| Line 14: | Line 14: | ||
==History of changes in FDA indication== | ==History of changes in FDA indication== | ||
| − | * 1989-01-27: Initial FDA approval for use in combination with LHRH agonistic | + | * 1989-01-27: Initial FDA approval for use in combination with LHRH agonistic analogs (such as leuprolide acetate) for the treatment of metastatic [[Prostate_cancer|prostatic carcinoma]] (stage D2). To achieve the benefit of the adjunctive therapy with EUFLEX, treatment must be started simultaneously using both drugs. EUFLEX Tablets are also indicated as an adjunctive therapy to orchiectomy, in order to achieve complete androgen blockade. ''(Based on SWOG-8494)'' |
* 1989-01-27: Also approved in combination with LHRH agonists are also indicated prior to and during definitive external beam radiotherapy for patients with bulky locally advanced Stage B2 and Stage C [[Prostate_cancer|prostatic carcinoma]]. ''(Based on Pilepich et al. 1995)'' | * 1989-01-27: Also approved in combination with LHRH agonists are also indicated prior to and during definitive external beam radiotherapy for patients with bulky locally advanced Stage B2 and Stage C [[Prostate_cancer|prostatic carcinoma]]. ''(Based on Pilepich et al. 1995)'' | ||
==History of changes in EMA indication== | ==History of changes in EMA indication== | ||
Revision as of 19:30, 23 June 2024
General information
Class/mechanism: Antiandrogen; non-steroidal. Inhibits androgen uptake and/or inhibits nuclear binding of androgen in target tissues.[1][2]
Route: PO
Extravasation: n/a
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
Patient drug information
- Flutamide (Eulexin) patient drug information (Chemocare)[3]
- Flutamide (Eulexin) patient drug information (UpToDate)[4]
History of changes in FDA indication
- 1989-01-27: Initial FDA approval for use in combination with LHRH agonistic analogs (such as leuprolide acetate) for the treatment of metastatic prostatic carcinoma (stage D2). To achieve the benefit of the adjunctive therapy with EUFLEX, treatment must be started simultaneously using both drugs. EUFLEX Tablets are also indicated as an adjunctive therapy to orchiectomy, in order to achieve complete androgen blockade. (Based on SWOG-8494)
- 1989-01-27: Also approved in combination with LHRH agonists are also indicated prior to and during definitive external beam radiotherapy for patients with bulky locally advanced Stage B2 and Stage C prostatic carcinoma. (Based on Pilepich et al. 1995)
History of changes in EMA indication
- 1982-03-24: EURD
Also known as
- Brand names: Cytomid, Euflex, Eulexin, Flutamid, Flutatec, Lutamide, Proscan, Tamid