Difference between revisions of "Teniposide (Vumon)"

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==General information==
 
==General information==
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Class/mechanism: Topoisomerase II inhibitor.  Teniposide inhibits type II topoisomerase, which results in single and double-stranded DNA breaks and DNA-protein crosslinks.  It is cell-cycle specific, acting in late S or early G2, preventing cells from entering mitosis.  It is dissolved in Cremophor EL (polyoxyethylated castor oil), which may cause hypersensitivity infusion reactions.<ref name="insert">[http://packageinserts.bms.com/pi/pi_vumon.pdf Teniposide (Vumon) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/teniposide.pdf Teniposide (Vumon) package insert (locally hosted backup)]</ref>
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Class/mechanism: Topoisomerase II inhibitor.  Teniposide inhibits type II topoisomerase, which results in single and double-stranded DNA breaks and DNA-protein crosslinks.  It is cell-cycle specific, acting in late S or early G2, preventing cells from entering mitosis.  It is dissolved in Cremophor EL (polyoxyethylated castor oil), which may cause hypersensitivity infusion reactions.<ref name="insert">[http://packageinserts.bms.com/pi/pi_vumon.pdf Teniposide (Vumon) package insert]</ref><ref>[https://hemonc.org/docs/packageinsert/teniposide.pdf Teniposide (Vumon) package insert (locally hosted backup)]</ref>
 
<br>Route: IV
 
<br>Route: IV
 
<br>Extravasation: [[irritant]]
 
<br>Extravasation: [[irritant]]
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[[Category:Irritant]]
 
[[Category:Irritant]]
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[[Category:Topoisomerase inhibitors]]
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[[Category:Topoisomerase II inhibitors]]
  
 
[[Category:B-cell acute lymphoblastic leukemia medications]]
 
[[Category:B-cell acute lymphoblastic leukemia medications]]

Revision as of 19:26, 23 June 2024

General information

Class/mechanism: Topoisomerase II inhibitor. Teniposide inhibits type II topoisomerase, which results in single and double-stranded DNA breaks and DNA-protein crosslinks. It is cell-cycle specific, acting in late S or early G2, preventing cells from entering mitosis. It is dissolved in Cremophor EL (polyoxyethylated castor oil), which may cause hypersensitivity infusion reactions.[1][2]
Route: IV
Extravasation: irritant

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Diseases for which it is used

Diseases for which it was used

Patient drug information

History of changes in FDA indication

History of changes in EMA indication

  • 1976-04-05: EURD

Also known as

  • Code name: VM-26
  • Brand name: Vumon

References

  1. ↑ 1.0 1.1 Teniposide (Vumon) package insert
  2. ↑ Teniposide (Vumon) package insert (locally hosted backup)
  3. ↑ Teniposide (Vumon) patient drug information (Chemocare)
  4. ↑ Teniposide (Vumon) patient drug information (UpToDate)
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