Difference between revisions of "Teniposide (Vumon)"

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==General information==
 
==General information==
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Class/mechanism: Topoisomerase II inhibitor.  Teniposide inhibits type II topoisomerase, which results in single and double-stranded DNA breaks and DNA-protein crosslinks.  It is cell-cycle specific, acting in late S or early G2, preventing cells from entering mitosis.  It is dissolved in Cremophor EL (polyoxyethylated castor oil), which may cause hypersensitivity infusion reactions.<ref name="insert">[http://packageinserts.bms.com/pi/pi_vumon.pdf Teniposide (Vumon) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/teniposide.pdf Teniposide (Vumon) package insert (locally hosted backup)]</ref>
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Class/mechanism: Topoisomerase II inhibitor.  Teniposide inhibits type II topoisomerase, which results in single and double-stranded DNA breaks and DNA-protein crosslinks.  It is cell-cycle specific, acting in late S or early G2, preventing cells from entering mitosis.  It is dissolved in Cremophor EL (polyoxyethylated castor oil), which may cause hypersensitivity infusion reactions.<ref name="insert">[http://packageinserts.bms.com/pi/pi_vumon.pdf Teniposide (Vumon) package insert]</ref><ref>[https://hemonc.org/docs/packageinsert/teniposide.pdf Teniposide (Vumon) package insert (locally hosted backup)]</ref>
 
<br>Route: IV
 
<br>Route: IV
 
<br>Extravasation: [[irritant]]
 
<br>Extravasation: [[irritant]]
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==Diseases for which it was used==
 
==Diseases for which it was used==
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*[[Diffuse large B-cell lymphoma - historical|Diffuse large B-cell lymphoma]]
 
*[[Follicular lymphoma_-_historical |Follicular lymphoma]]
 
*[[Follicular lymphoma_-_historical |Follicular lymphoma]]
  
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*[http://chemocare.com/bio/teniposide.asp Teniposide (Vumon) patient drug information (Chemocare)]<ref>[http://chemocare.com/bio/teniposide.asp Teniposide (Vumon) patient drug information (Chemocare)]</ref>
 
*[http://chemocare.com/bio/teniposide.asp Teniposide (Vumon) patient drug information (Chemocare)]<ref>[http://chemocare.com/bio/teniposide.asp Teniposide (Vumon) patient drug information (Chemocare)]</ref>
 
*[http://www.uptodate.com/contents/teniposide-patient-drug-information Teniposide (Vumon) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/teniposide-patient-drug-information Teniposide (Vumon) patient drug information (UpToDate)]</ref>
 
*[http://www.uptodate.com/contents/teniposide-patient-drug-information Teniposide (Vumon) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/teniposide-patient-drug-information Teniposide (Vumon) patient drug information (UpToDate)]</ref>
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==History of changes in FDA indication==
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* 1992-07-14: Initial approval for induction therapy in patients with refractory childhood [[:Category:Acute lymphoblastic leukemias|acute lymphoblastic leukemia]]
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==History of changes in EMA indication==
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*1976-04-05: EURD
  
 
==Also known as==
 
==Also known as==
 
*'''Code name:''' VM-26
 
*'''Code name:''' VM-26
 
*'''Brand name:''' Vumon
 
*'''Brand name:''' Vumon
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−
==History of changes in FDA indication==
 
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* 7/14/1992: Initial FDA approval
 
  
 
==References==
 
==References==
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[[Category:Irritant]]
 
[[Category:Irritant]]
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[[Category:Topoisomerase inhibitors]]
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[[Category:Topoisomerase II inhibitors]]
  
 
[[Category:B-cell acute lymphoblastic leukemia medications]]
 
[[Category:B-cell acute lymphoblastic leukemia medications]]
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[[Category:Low-grade glioma medications]]
 
[[Category:Low-grade glioma medications]]
 
[[Category:Small cell lung cancer medications]]
 
[[Category:Small cell lung cancer medications]]
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[[Category:Diffuse large B-cell lymphoma medications (historic)]]
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[[Category:Follicular lymphoma medications (historic)]]
  
 
[[Category:FDA approved in 1992]]
 
[[Category:FDA approved in 1992]]
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[[Category:EMA approved in 1976]]

Revision as of 19:26, 23 June 2024

General information

Class/mechanism: Topoisomerase II inhibitor. Teniposide inhibits type II topoisomerase, which results in single and double-stranded DNA breaks and DNA-protein crosslinks. It is cell-cycle specific, acting in late S or early G2, preventing cells from entering mitosis. It is dissolved in Cremophor EL (polyoxyethylated castor oil), which may cause hypersensitivity infusion reactions.[1][2]
Route: IV
Extravasation: irritant

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Diseases for which it is used

Diseases for which it was used

Patient drug information

History of changes in FDA indication

History of changes in EMA indication

  • 1976-04-05: EURD

Also known as

  • Code name: VM-26
  • Brand name: Vumon

References

  1. ↑ 1.0 1.1 Teniposide (Vumon) package insert
  2. ↑ Teniposide (Vumon) package insert (locally hosted backup)
  3. ↑ Teniposide (Vumon) patient drug information (Chemocare)
  4. ↑ Teniposide (Vumon) patient drug information (UpToDate)
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