Difference between revisions of "Tegafur and uracil (UFT)"

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''Note: this drug combination is not FDA approved but is used widely in other countries.''
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==General information==
 
==General information==
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Class/mechanism: <ref name="insert">[**PUT PDF FILE HERE** Uracil-tegafur (UFT) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/uraciltegafur.pdf Uracil-tegafur (UFT) package insert (locally hosted backup)]</ref>
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Class/mechanism: Contains a fixed molar ratio (4:1) of uracil to tegafur.  Tegafur is metabolized in vivo to [[Fluorouracil (5-FU)]], which is a pyrimidine analog antimetabolite that is metabolized to 5-fluoro-2'-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP).  FdUMP inhibits DNA synthesis by binding to thymidylate synthase and inhibiting production of thymidylate; FUTP interferes with RNA processing when it is mistakenly incorporated in place of uridine triphosphate (UTP).  Uracil helps to maintain intracellular levels of [[Fluorouracil (5-FU)]] by inhibiting its degradation.<ref name="insert">[http://hemonc.org/docs/packageinsert/uraciltegafur.pdf Uracil-tegafur (UFT) package insert]; adapted from source: [http://home.intekom.com/pharm/bm_squib/uft.html South African Electronic Package Inserts]</ref><ref>[http://home.intekom.com/pharm/bm_squib/uft.html Uracil-tegafur (UFT) information]</ref><ref>[http://www.merckserono.com/en/products/oncology/colorectal_cancer/uft/uft.html UFT manufacturer's site]</ref>
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<br>Route: TBD
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<br>Route: PO
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<br>Extravasation: TBD
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<br>Extravasation: n/a
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For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref>
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==Patient safety==
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EMA has recommended that patients should be tested for the lack of the enzyme dihydropyrimidine dehydrogenase (DPD) before starting cancer treatment with fluorouracil given by injection or infusion (drip) or with the related medicines, capecitabine and tegafur.
  
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For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer.  Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the package insert<ref name="insert"></ref>.
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==Diseases for which it is used==
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*[[Colorectal cancer]]
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**[[Colon cancer]]
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**[[Rectal cancer]]
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*[[Esophageal cancer]]
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*[[Gastric cancer]]
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*[[Head and neck cancer]]
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*[[Non-small cell lung cancer]]
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**[[Non-small cell lung cancer, nonsquamous]]
  
 
==Patient drug information==
 
==Patient drug information==
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*[http://www.uptodate.com/contents/uraciltegafur-patient-drug-information Uracil-tegafur (UFT) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/uraciltegafur-patient-drug-information Uracil-tegafur (UFT) patient drug information (UpToDate)]</ref>
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*[http://www.cancernet.co.uk/uftoral.htm Uracil-tegafur (UFT) patient information site]<ref>[http://www.cancernet.co.uk/uftoral.htm Uracil-tegafur (UFT) patient information site]</ref>
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*[http://www.macmillan.org.uk/Cancerinformation/Cancertreatment/Treatmenttypes/Chemotherapy/Individualdrugs/Tegafur-uracil.aspx Macmillan Uracil-tegafur (UFT) patient information]<ref>[http://www.macmillan.org.uk/Cancerinformation/Cancertreatment/Treatmenttypes/Chemotherapy/Individualdrugs/Tegafur-uracil.aspx Macmillan Uracil-tegafur (UFT) patient information]</ref>
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==Also known as==
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*'''Generic name:''' tegafur-uracil
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*'''Brand names:''' Ftorafur, Luporal, Tefudex, Ufur, Uftoral, Uracel
  
 
==References==
 
==References==
 
<references/>
 
<references/>
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[[Category:Drugs]]
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[[Category:Combination drugs]]
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[[Category:Oral medications]]
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[[Category:Fluoropyrimidines]]
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[[Category:Colorectal cancer medications]]
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[[Category:Colon cancer medications]]
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[[Category:Esophageal cancer medications]]
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[[Category:Gastric cancer medications]]
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[[Category:Head and neck cancer medications]]
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[[Category:Non-small cell lung cancer medications]]
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[[Category:Non-small cell lung cancer, nonsquamous medications]]
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[[Category:Rectal cancer medications]]
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[[Category:PMDA approved drugs]]

Revision as of 01:18, 7 November 2023

Note: this drug combination is not FDA approved but is used widely in other countries.

General information

Class/mechanism: Contains a fixed molar ratio (4:1) of uracil to tegafur. Tegafur is metabolized in vivo to Fluorouracil (5-FU), which is a pyrimidine analog antimetabolite that is metabolized to 5-fluoro-2'-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP). FdUMP inhibits DNA synthesis by binding to thymidylate synthase and inhibiting production of thymidylate; FUTP interferes with RNA processing when it is mistakenly incorporated in place of uridine triphosphate (UTP). Uracil helps to maintain intracellular levels of Fluorouracil (5-FU) by inhibiting its degradation.[1][2][3]
Route: PO
Extravasation: n/a

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Patient safety

EMA has recommended that patients should be tested for the lack of the enzyme dihydropyrimidine dehydrogenase (DPD) before starting cancer treatment with fluorouracil given by injection or infusion (drip) or with the related medicines, capecitabine and tegafur.

Diseases for which it is used

Patient drug information

Also known as

  • Generic name: tegafur-uracil
  • Brand names: Ftorafur, Luporal, Tefudex, Ufur, Uftoral, Uracel

References

  1. ↑ 1.0 1.1 Uracil-tegafur (UFT) package insert; adapted from source: South African Electronic Package Inserts
  2. ↑ Uracil-tegafur (UFT) information
  3. ↑ UFT manufacturer's site
  4. ↑ Uracil-tegafur (UFT) patient information site
  5. ↑ Macmillan Uracil-tegafur (UFT) patient information
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