Difference between revisions of "Sargramostim (Leukine)"
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==General information== | ==General information== | ||
| − | Class/mechanism: Recombinant human granulocyte macrophage colony stimulating factor (GM-CSF), hematopoietic growth factor. Sargramostim binds to cell surface receptors and stimulates survival, proliferation, and differentiation of hematopoietic progenitor cells. In addition to triggering the proliferation of neutrophils, monocytes/macrophages, and myeloid-derived dendritic cells, GM-CSF has also been observed to activate mature granulocytes and macrophages.<ref name="insert">[http://products.sanofi.us/Leukine/Leukine.pdf Sargramostim (Leukine/GM-CSF) package insert]</ref><ref>[[File:Sargramostim.pdf|Sargramostim (Leukine/GM-CSF) package insert (locally hosted backup)]]</ref><ref>[http://www.leukine.com Leukine manufacturer's website]</ref> | + | Class/mechanism: Recombinant human granulocyte macrophage colony stimulating factor (GM-CSF), hematopoietic growth factor. Sargramostim binds to cell surface receptors and stimulates survival, proliferation, and differentiation of hematopoietic progenitor cells. In addition to triggering the proliferation of neutrophils, monocytes/macrophages, and myeloid-derived dendritic cells, GM-CSF has also been observed to activate mature granulocytes and macrophages.<ref name="insert">[http://products.sanofi.us/Leukine/Leukine.pdf Sargramostim (Leukine/GM-CSF) package insert]</ref><ref>[[:File:Sargramostim.pdf|Sargramostim (Leukine/GM-CSF) package insert (locally hosted backup)]]</ref><ref>[http://www.leukine.com Leukine manufacturer's website]</ref> |
<br>Route: SC, IV | <br>Route: SC, IV | ||
<br>Extravasation: no information | <br>Extravasation: no information | ||
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==Diseases for which it is used== | ==Diseases for which it is used== | ||
''Note: sargramostim does not have a known direct antineoplastic effect. However, it has been used as an adjunct for immunotherapy trials.'' | ''Note: sargramostim does not have a known direct antineoplastic effect. However, it has been used as an adjunct for immunotherapy trials.'' | ||
| + | *[[Melanoma]] | ||
*[[Neuroblastoma]] | *[[Neuroblastoma]] | ||
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[[Category:Granulocyte macrophage colony-stimulating factors]] | [[Category:Granulocyte macrophage colony-stimulating factors]] | ||
| + | [[Category:Melanoma medications]] | ||
[[Category:Neuroblastoma medications]] | [[Category:Neuroblastoma medications]] | ||
[[Category:FDA approved in 1991]] | [[Category:FDA approved in 1991]] | ||
Latest revision as of 00:53, 7 November 2023
General information
Class/mechanism: Recombinant human granulocyte macrophage colony stimulating factor (GM-CSF), hematopoietic growth factor. Sargramostim binds to cell surface receptors and stimulates survival, proliferation, and differentiation of hematopoietic progenitor cells. In addition to triggering the proliferation of neutrophils, monocytes/macrophages, and myeloid-derived dendritic cells, GM-CSF has also been observed to activate mature granulocytes and macrophages.[1][2][3]
Route: SC, IV
Extravasation: no information
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
Note: sargramostim does not have a known direct antineoplastic effect. However, it has been used as an adjunct for immunotherapy trials.
Patient drug information
- Sargramostim (Leukine/GM-CSF) package insert[1]
- Sargramostim (Leukine/GM-CSF) patient drug information (Chemocare)[4]
- Sargramostim (Leukine/GM-CSF) patient drug information (UpToDate)[5]
Also known as
- Generic names: GMCSF, GM-CSF, granulocyte macrophage colony stimulating factor
- Brand name: Leukine