Difference between revisions of "Carmofur (HCFU)"
Jump to navigation
Jump to search
(Created page with "==General information== Class/mechanism: Pyrimidine analog, antimetabolite, inhibitor of thymidylate synthase. Converted in vivo to fluorouracil (5-FU), which is metaboliz...") |
m |
||
(One intermediate revision by the same user not shown) | |||
Line 7: | Line 7: | ||
*'''Generic names:''' HCFU, hexylcarbamoyl fluorouracil | *'''Generic names:''' HCFU, hexylcarbamoyl fluorouracil | ||
+ | ==References== | ||
[[Category:Drugs]] | [[Category:Drugs]] | ||
[[Category:Oral medications]] | [[Category:Oral medications]] | ||
[[Category:Fluoropyrimidines]] | [[Category:Fluoropyrimidines]] | ||
+ | |||
+ | [[Category:PMDA approved in 1981]] | ||
[[Category:Stub]] | [[Category:Stub]] |
Latest revision as of 22:20, 1 October 2023
General information
Class/mechanism: Pyrimidine analog, antimetabolite, inhibitor of thymidylate synthase. Converted in vivo to fluorouracil (5-FU), which is metabolized to 5-fluoro-2'-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP). FdUMP inhibits DNA synthesis by binding to thymidylate synthase and inhibiting production of thymidylate; FUTP interferes with RNA processing when it is mistakenly incorporated in place of uridine triphosphate (UTP).[1][2][3]
Route: PO
Extravasation: n/a
Also known as
- Generic names: HCFU, hexylcarbamoyl fluorouracil