Difference between revisions of "Tivozanib (Fotivda)"
Jump to navigation
Jump to search
m |
m |
||
| Line 2: | Line 2: | ||
From the [http://www.cancer.gov/publications/dictionaries/cancer-drug?CdrID=561728 NCI Drug Dictionary]: An orally bioavailable inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2 and 3 with potential antiangiogenic and antineoplastic activities. Tivozanib binds to and inhibits VEGFRs 1, 2 and 3, which may result in the inhibition of endothelial cell migration and proliferation, inhibition of tumor angiogenesis and tumor cell death.<ref name="insert">[https://www.fotivdahcp.com/fotivdapi.pdf Tivozanib (Fotivda) package insert]</ref><ref>[[:File:Tivozanib.pdf | Tivozanib (Fotivda) package insert (locally hosted backup)]]</ref><ref>[https://www.fotivda.com/ Fotivda manufacturer's website]</ref> | From the [http://www.cancer.gov/publications/dictionaries/cancer-drug?CdrID=561728 NCI Drug Dictionary]: An orally bioavailable inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2 and 3 with potential antiangiogenic and antineoplastic activities. Tivozanib binds to and inhibits VEGFRs 1, 2 and 3, which may result in the inhibition of endothelial cell migration and proliferation, inhibition of tumor angiogenesis and tumor cell death.<ref name="insert">[https://www.fotivdahcp.com/fotivdapi.pdf Tivozanib (Fotivda) package insert]</ref><ref>[[:File:Tivozanib.pdf | Tivozanib (Fotivda) package insert (locally hosted backup)]]</ref><ref>[https://www.fotivda.com/ Fotivda manufacturer's website]</ref> | ||
| − | ==Diseases for which it is established | + | ==Diseases for which it is established== |
*[[Renal cell carcinoma]] | *[[Renal cell carcinoma]] | ||
Revision as of 13:07, 16 September 2023
Mechanism of action
From the NCI Drug Dictionary: An orally bioavailable inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2 and 3 with potential antiangiogenic and antineoplastic activities. Tivozanib binds to and inhibits VEGFRs 1, 2 and 3, which may result in the inhibition of endothelial cell migration and proliferation, inhibition of tumor angiogenesis and tumor cell death.[1][2][3]
Diseases for which it is established
Patient drug information
History of changes in FDA indication
- 2021-03-10: Approved for adult patients with relapsed or refractory advanced renal cell carcinoma (RCC) following two or more prior systemic therapies. (Based on TIVO-3)
History of changes in EMA indication
- 2017-08-24: Initial authorization for first line treatment of adult patients with advanced renal cell carcinoma (RCC). (Based on TIVO-1)
- 2017-08-24: Initial authorization for adult patients who are VEGFR and mTOR pathway inhibitor-naïve following disease progression after one prior treatment with cytokine therapy for advanced RCC. (Based on TIVO-1)
Also known as
- Code name: AV-951
- Brand name: Fotivda