Difference between revisions of "Pixantrone (Pixuvri)"
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*Uncertain date: Pixuvri is indicated as monotherapy for the treatment of adult patients with multiply relapsed or refractory [[:Category:Aggressive non-Hodgkin lymphomas|aggressive non-Hodgkin B-cell lymphomas (NHL)]]. The benefit of pixantrone treatment has not been established in patients when used as fifth-line or greater chemotherapy in patients who are refractory to last therapy. | *Uncertain date: Pixuvri is indicated as monotherapy for the treatment of adult patients with multiply relapsed or refractory [[:Category:Aggressive non-Hodgkin lymphomas|aggressive non-Hodgkin B-cell lymphomas (NHL)]]. The benefit of pixantrone treatment has not been established in patients when used as fifth-line or greater chemotherapy in patients who are refractory to last therapy. | ||
==Also known as== | ==Also known as== | ||
| − | *'''Code name:''' BBR 2778 | + | *'''Code name:''' BBR-2778 |
*'''Generic name:''' pixantrone dimaleate | *'''Generic name:''' pixantrone dimaleate | ||
*'''Brand name:''' Pixuvri | *'''Brand name:''' Pixuvri | ||
Revision as of 13:01, 8 September 2023
Mechanism of action
From the NCI Drug Dictionary: The dimaleate salt of a synthetic, noncardiotoxic aza-anthracenedione analogue with potential antineoplastic activity. Pixantrone intercalates into DNA and induces topoisomerase II-mediated DNA strand crosslinks, resulting in inhibition of DNA replication and tumor cell cytotoxicity. Route: IV
Diseases for which it is used
History of changes in EMA indication
- 2012-05-10: Initial authorization as Pixuvri
- Uncertain date: Pixuvri is indicated as monotherapy for the treatment of adult patients with multiply relapsed or refractory aggressive non-Hodgkin B-cell lymphomas (NHL). The benefit of pixantrone treatment has not been established in patients when used as fifth-line or greater chemotherapy in patients who are refractory to last therapy.
Also known as
- Code name: BBR-2778
- Generic name: pixantrone dimaleate
- Brand name: Pixuvri