Difference between revisions of "Hypercoagulable state (thrombophilia)"
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==Inherited thrombophilias== | ==Inherited thrombophilias== | ||
*Prothrombin gene mutation (G20210A) | *Prothrombin gene mutation (G20210A) | ||
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==Acquired thrombophilias and clotting risk factors== | ==Acquired thrombophilias and clotting risk factors== | ||
| − | *Surgery, foreign bodies such as venous catheters, smoking, obesity, elevated factor VIII, advanced age, male sex, trauma, sedentary state, immobilization, malignancy, myeloproliferative disorders--[[polycythemia vera | polycythemia vera (PV)]], [[Essential thrombocythemia | essential thrombocythemia (ET)]], [[Myelofibrosis | primary myelofibrosis (PMF)]], pregnancy, medications--e.g. [[Bevacizumab (Avastin)]], [[Lenalidomide (Revlimid)]], [[Thalidomide (Thalomid)]], [[Tamoxifen (Nolvadex)]], oral contraceptive use, [[heparin]]--in the case of heparin-induced thrombocytopenia/thrombosis (HIT), congestive heart failure, anatomic/low cardiovascular flow states--e.g. inferior vena cava (IVC) abnormalities, chronic inflammation, inflammatory bowel disease, nephrotic syndrome, [[ | + | *[[Surgery]], foreign bodies such as venous catheters, smoking, obesity, elevated factor VIII, advanced age, male sex, trauma, sedentary state, immobilization, malignancy, myeloproliferative disorders--[[polycythemia vera | polycythemia vera (PV)]], [[Essential thrombocythemia | essential thrombocythemia (ET)]], [[Myelofibrosis | primary myelofibrosis (PMF)]], pregnancy, medications--e.g. [[Bevacizumab (Avastin)]], [[Lenalidomide (Revlimid)]], [[Thalidomide (Thalomid)]], [[Tamoxifen (Nolvadex)]], oral contraceptive use, [[heparin]]--in the case of heparin-induced thrombocytopenia/thrombosis (HIT), congestive heart failure, anatomic/low cardiovascular flow states--e.g. inferior vena cava (IVC) abnormalities, chronic inflammation, inflammatory bowel disease, nephrotic syndrome, [[Paroxysmal_nocturnal_hemoglobinuria | paroxysmal noctural hemoglobinuria (PNH)]] |
*Prior venous thromboembolism (VTE) | *Prior venous thromboembolism (VTE) | ||
*Antiphospholipid antibody syndrome (APS) | *Antiphospholipid antibody syndrome (APS) | ||
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**Beta 2 glycoprotein 1 (B2GP1) IgG, IgM, IgA | **Beta 2 glycoprotein 1 (B2GP1) IgG, IgM, IgA | ||
**Sapporo criteria for APS | **Sapporo criteria for APS | ||
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| + | ==Related pages== | ||
| + | *[[Antiphospholipid antibody syndrome]] | ||
| + | *[[Inherited thrombophilia]] | ||
| + | *[[Venous thromboembolism]] | ||
==References== | ==References== | ||
| + | *[https://pubmed.ncbi.nlm.nih.gov/25724822 Moll S. Thrombophilia: clinical-practical aspects. J Thromb Thrombolysis. 2015 Apr;39(3):367-78.] | ||
| + | **[https://mobile.twitter.com/THilalMD/status/1183941575300263936 Table of reliability of thrombophilia testing with anticoagulants and in acute thrombosis] | ||
[[Category:Hematology reference pages]] | [[Category:Hematology reference pages]] | ||
Latest revision as of 17:51, 7 September 2023
Inherited thrombophilias
- Prothrombin gene mutation (G20210A)
- Factor V Leiden mutation
- Antithrombin III deficiency
- Protein C deficiency
- Protein S deficiency
- Dysfibrinogenemia
Controversial:
- Plasminogen deficiency
- Factor XII deficiency
Acquired thrombophilias and clotting risk factors
- Surgery, foreign bodies such as venous catheters, smoking, obesity, elevated factor VIII, advanced age, male sex, trauma, sedentary state, immobilization, malignancy, myeloproliferative disorders-- polycythemia vera (PV), essential thrombocythemia (ET), primary myelofibrosis (PMF), pregnancy, medications--e.g. Bevacizumab (Avastin), Lenalidomide (Revlimid), Thalidomide (Thalomid), Tamoxifen (Nolvadex), oral contraceptive use, heparin--in the case of heparin-induced thrombocytopenia/thrombosis (HIT), congestive heart failure, anatomic/low cardiovascular flow states--e.g. inferior vena cava (IVC) abnormalities, chronic inflammation, inflammatory bowel disease, nephrotic syndrome, paroxysmal noctural hemoglobinuria (PNH)
- Prior venous thromboembolism (VTE)
- Antiphospholipid antibody syndrome (APS)
- Lupus anticoagulant: dilute Russell viper venom time (dRVVT), dilute activated partial thromboplastin time (dAPTT), Staclot LA (hexagonal phase phospholipids), Kaolin clotting time (KCT)
- Anticardiolipin (aCL) antibody IgG, IgM, IgA
- Beta 2 glycoprotein 1 (B2GP1) IgG, IgM, IgA
- Sapporo criteria for APS