Difference between revisions of "Anagrelide (Agrylin)"
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==General information== | ==General information== | ||
− | Class/mechanism: Interferes with maturation of platelets from megakaryocytes, phosphodiesterase inhibitor.<ref name="insert">[ | + | Class/mechanism: Interferes with maturation of platelets from megakaryocytes, phosphodiesterase inhibitor.<ref name="insert">[https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020333s017lbl.pdf Anagrelide (Agrylin) package insert]</ref><ref>[[:File:Anagrelide.pdf | Anagrelide (Agrylin) package insert (locally hosted backup)]]</ref> |
<br>Route: PO | <br>Route: PO | ||
<br>Extravasation: n/a | <br>Extravasation: n/a | ||
− | *Example of usage: Anagrelide (Agrylin) 0.5 mg PO | + | *Example of usage: Anagrelide (Agrylin) 0.5 mg PO four times per day or 1 mg PO twice per day, titrate to the lowest effective dose to maintain platelets below 600,000, maximum increase in dose of 0.5 mg/day every week (max dose: 10 mg/day, 2.5 mg in a single dose) |
− | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. | + | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://reference.medscape.com/drug/agrylin-anagrelide-342140 Medscape], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> |
==Diseases for which it is used== | ==Diseases for which it is used== | ||
*[[Essential thrombocythemia]] | *[[Essential thrombocythemia]] | ||
+ | *[[Polycythemia vera]] | ||
==Patient drug information== | ==Patient drug information== | ||
− | *[ | + | *[https://chemocare.com/druginfo/anagrelide.aspx Anagrelide (Agrylin) patient drug information (Chemocare)]<ref>[https://chemocare.com/druginfo/anagrelide.aspx Anagrelide (Agrylin) patient drug information (Chemocare)]</ref> |
*[http://www.uptodate.com/contents/anagrelide-patient-drug-information Anagrelide (Agrylin) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/anagrelide-patient-drug-information Anagrelide (Agrylin) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/anagrelide-patient-drug-information Anagrelide (Agrylin) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/anagrelide-patient-drug-information Anagrelide (Agrylin) patient drug information (UpToDate)]</ref> | ||
+ | ==History of changes in PMDA indication== | ||
+ | *2014-09-26: Initial approval for the treatment of [[essential thrombocythemia]]. | ||
==Also known as== | ==Also known as== | ||
*'''Brand names:''' Agrylin, Xagrid | *'''Brand names:''' Agrylin, Xagrid | ||
Line 21: | Line 24: | ||
<references/> | <references/> | ||
− | [[Category: | + | [[Category:Drugs]] |
[[Category:Oral medications]] | [[Category:Oral medications]] | ||
[[Category:Hematology medications]] | [[Category:Hematology medications]] | ||
Line 27: | Line 30: | ||
[[Category:Essential thrombocythemia medications]] | [[Category:Essential thrombocythemia medications]] | ||
+ | [[Category:Polycythemia vera medications]] | ||
− | [[Category: | + | [[Category:FDA approved in 1997]] |
+ | [[Category:EMA approved in 2004]] | ||
+ | [[Category:PMDA approved in 2014]] |
Latest revision as of 23:52, 2 September 2023
General information
Class/mechanism: Interferes with maturation of platelets from megakaryocytes, phosphodiesterase inhibitor.[1][2]
Route: PO
Extravasation: n/a
- Example of usage: Anagrelide (Agrylin) 0.5 mg PO four times per day or 1 mg PO twice per day, titrate to the lowest effective dose to maintain platelets below 600,000, maximum increase in dose of 0.5 mg/day every week (max dose: 10 mg/day, 2.5 mg in a single dose)
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, Medscape, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
Patient drug information
- Anagrelide (Agrylin) patient drug information (Chemocare)[3]
- Anagrelide (Agrylin) patient drug information (UpToDate)[4]
History of changes in PMDA indication
- 2014-09-26: Initial approval for the treatment of essential thrombocythemia.
Also known as
- Brand names: Agrylin, Xagrid