Difference between revisions of "Tislelizumab (Baizean)"
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m (Jwarner moved page Tislelizumab (BGB-A317) to Tislelizumab (Baizean): brand name) |
Revision as of 02:23, 11 August 2023
Mechanism of action
From the NCI Drug Dictionary: A monoclonal antibody directed against the negative immunoregulatory human cell surface receptor programmed cell death 1 (PD-1), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, tislelizumab binds to PD-1 and inhibits the binding of PD-1 to the PD-1 ligands programmed cell death-1 ligand 1 (PD-L1), and PD-1 ligand 2 (PD-L2). This prevents the activation of PD-1 and its downstream signaling pathways. This may restore immune function through the activation of both T cells and T-cell-mediated immune responses against tumor cells.
Diseases for which it is used
- Bladder cancer
- Esophageal squamous cell carcinoma
- Hepatocellular carcinoma
- Classical Hodgkin lymphoma
- Nasopharyngeal carcinoma
- Non-small cell lung cancer
History of changes in NMPA indication
- 2019-12-26: Initial approval
Also known as
- Code name: BGB-A317
- Generic name: tilelizumab
- Brand name: Baizean
Categories:
- Drugs
- Intravenous medications
- Anti-PD-1 antibodies
- Bladder cancer medications
- Esophageal cancer medications
- Hepatocellular carcinoma medications
- Classical Hodgkin lymphoma medications
- Nasopharyngeal carcinoma medications
- Non-small cell lung cancer medications
- Non-small cell lung cancer, nonsquamous medications
- Non-small cell lung cancer, squamous medications
- NMPA approved in 2019