Difference between revisions of "Fluorouracil (5-FU)"
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(Created page with "==General information== Class/mechanism: <ref name="insert">[http://patient.cancerconsultants.com/druginserts/Fluorouracil.pdf Fluorouracil (5-FU) package insert]</ref><ref>[http...") |
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| + | Also known as Adrucil. | ||
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==General information== | ==General information== | ||
| − | Class/mechanism: <ref name="insert">[http://patient.cancerconsultants.com/druginserts/Fluorouracil.pdf Fluorouracil (5-FU) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/fluorouracil.pdf Fluorouracil (5-FU) package insert (locally hosted backup)]</ref> | + | Class/mechanism: Pyrimidine analog, antimetabolite, inhibitor of thymidylate synthase. Inhibits the methylation reaction of deoxyuridylic acid to thymidylic acid, interfering with DNA and RNA synthesis.<ref name="insert">[http://patient.cancerconsultants.com/druginserts/Fluorouracil.pdf Fluorouracil (5-FU) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/fluorouracil.pdf Fluorouracil (5-FU) package insert (locally hosted backup)]</ref> [http://en.wikipedia.org/wiki/Fluorouracil#Interactive_pathway_map 5-FU pathway]. |
| − | <br>Route: | + | <br>Route: IV |
| − | <br>Extravasation: | + | <br>Extravasation: [[irritant]] |
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the package insert<ref name="insert"></ref>. | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the package insert<ref name="insert"></ref>. | ||
Revision as of 00:13, 16 January 2012
Also known as Adrucil.
General information
Class/mechanism: Pyrimidine analog, antimetabolite, inhibitor of thymidylate synthase. Inhibits the methylation reaction of deoxyuridylic acid to thymidylic acid, interfering with DNA and RNA synthesis.[1][2] 5-FU pathway.
Route: IV
Extravasation: irritant
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the package insert[1].
Patient drug information
- Fluorouracil (5-FU) patient drug information (Chemocare)[3]
- Fluorouracil (5-FU) patient drug information (UpToDate)[4]