Difference between revisions of "Staging page"

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[[#top|Back to Top]]
 
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{{#lst:Section editor transclusions|peds}}
 
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<big>''This page contains studies that were specific to pediatric populations. For the more general Hodgkin lymphoma page, follow [[Hodgkin lymphoma|this link]].</big><br><br>
 
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''Are you looking for a regimen but can't find it here? It is possible that we've moved it to the [[Hodgkin_lymphoma_-_historical|historical regimens page]]. For placebo or observational studies in this condition, please visit [[Hodgkin lymphoma - null regimens|this page]]. If you still can't find it, please let us know so we can add it.''<br>
 
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{| class="wikitable" style="float:right; margin-right: 5px;"
 
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|-
 
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|<div style="background-color: #fee0d1; border: 1px solid #808000; padding: 5px; {{border-radius|16px}}" align="right"><font size="4"><b>{{#ask: [[-Has subobject::{{FULLPAGENAME}}]] |?Regimen |limit=10000|format=sum}} [[Tutorial#Regimens|regimens]] on this page</b></font></div>
 
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<div style="background-color: #deebf6; border: 1px solid #808000; padding: 5px; {{border-radius|16px}}"><font size="4"><b>{{#ask: [[-Has subobject::{{FULLPAGENAME}}]] |?Variant |limit=10000|format=sum}} [[Tutorial#Variants|variants]] on this page</b></font></div>
 
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|}
 
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{{TOC limit|limit=4}}
 
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=Guidelines=
 
−
==[https://www.nccn.org/ NCCN]==
 
−
*[https://www.nccn.org/professionals/physician_gls/pdf/ped_hodgkin.pdf NCCN Guidelines - Hodgkin Lymphoma (Pediatric and AYA)]
 
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=Upfront Therapy, High Risk=
 
−
==ABVE-PC {{#subobject:67406e|Regimen=1}}==
 
−
ABVE-PC: '''<u>A</u>'''driamycin (Doxorubicin), '''<u>B</u>'''leomycin, '''<u>V</u>'''incristine, '''<u>E</u>'''toposide, '''<u>P</u>'''rednisone, '''<u>C</u>'''yclophosphamide
 
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<div class="toccolours" style="background-color:#eeeeee">
 
−
===Regimen {{#subobject:9134b2|Variant=1}}===
 
−
{| class="wikitable sortable" style="width: 100%; text-align:center;"
 
−
!style="width: 20%"|Study
 
−
!style="width: 20%"|Years of enrollment
 
−
!style="width: 20%"|[[Levels_of_Evidence#Evidence|Evidence]]
 
−
!style="width: 20%"|Comparator
 
−
!style="width: 20%"|[[Levels_of_Evidence#Comparative_efficacy|Comparative Efficacy]]
 
−
|-
 
−
|[https://doi.org/10.1056/nejmoa2206660 Castellino et al. 2022 (COG AHOD1331)]
 
−
|2015-2019
 
−
| style="background-color:#1a9851" |Phase 3 (C)
 
−
|[[#Bv-AVEPC|Bv-AVEPC]]
 
−
| style="background-color:#d73027" |Inferior EFS
 
−
|-
 
−
|}
 
−
<div class="toccolours" style="background-color:#b3e2cd">
 
−
====Chemotherapy====
 
−
*[[Doxorubicin (Adriamycin)]] 25 mg/m<sup>2</sup> IV push or intermittent infusion once per day on days 1 & 2
 
−
**Concentration not to exceed 2 mg/mL
 
−
**IV push over 1 to 5 minutes or by intermittent infusion over 1 to 15 minutes; may prolong to 60 minutes if institutional policies mandate
 
−
*[[Bleomycin (Blenoxane)]] 5 units/m<sup>2</sup> IV over 10 to 20 minutes or SC once on day 1, then 10 units/m<sup>2</sup> IV over 10 to 20 minutes or SC once on day 8
 
−
*[[Vincristine (Oncovin)]] 1.4 mg/m<sup>2</sup> (maximum dose of 2.8 mg) IV once per day on days 1 & 8
 
−
*[[Etoposide (Vepesid)]] 125 mg/m<sup>2</sup> IV over 60 to 120 minutes once per day on days 1 to 3
 
−
**Rate should not exceed 300 mg/m<sup>2</sup>
 
−
*[[Cyclophosphamide (Cytoxan)]] 600 mg/m<sup>2</sup> IV over 30 to 60 minutes once per day on days 1 & 2
 
−
====Glucocorticoid therapy====
 
−
*[[Prednisone (Sterapred)]] 20 mg/m<sup>2</sup> PO twice per day on days 1 to 7
 
−
====Supportive therapy====
 
−
*[[Filgrastim (Neupogen)]] 5 mcg/kg SC (preferred) or IV once per day beginning on day 4, 5, 6, 7, 8, or 9, per institutional policy and continuing until ANC greater than 1000/uL
 
−
**Alternative: [[Pegfilgrastim (Neulasta)]] 100 mcg/kg (Maximum dose of 6 mg) SC once on day 4, 5, or 6
 
−
'''21-day cycle for 2 cycles, then response evaluation, then 21-day cycle for 3 cycles'''
 
−
</div></div>
 
−
===References===
 
−
# '''COG AHOD1331:''' Castellino SM, Pei Q, Parsons SK, Hodgson D, McCarten K, Horton T, Cho S, Wu Y, Punnett A, Dave H, Henderson TO, Hoppe BS, Charpentier AM, Keller FG, Kelly KM. Brentuximab Vedotin with Chemotherapy in Pediatric High-Risk Hodgkin's Lymphoma. N Engl J Med. 2022 Nov 3;387(18):1649-1660. [https://doi.org/10.1056/nejmoa2206660 link to original article] [https://pubmed.ncbi.nlm.nih.gov/36322844/ PubMed] NCT02166463
 
−
==Bv-AVEPC {{#subobject:67y7uj|Regimen=1}}==
 
−
Bv-AVEPC: '''<u>B</u>'''rentuximab '''<u>v</u>'''edotin, '''<u>A</u>'''driamycin (Doxorubicin), '''<u>V</u>'''incristine, '''<u>E</u>'''toposide, '''<u>P</u>'''rednisone, '''<u>C</u>'''yclophosphamide
 
−
<div class="toccolours" style="background-color:#eeeeee">
 
−
===Regimen {{#subobject:1nc4b2|Variant=1}}===
 
−
{| class="wikitable sortable" style="width: 100%; text-align:center;"
 
−
!style="width: 20%"|Study
 
−
!style="width: 20%"|Years of enrollment
 
−
!style="width: 20%"|[[Levels_of_Evidence#Evidence|Evidence]]
 
−
!style="width: 20%"|Comparator
 
−
!style="width: 20%"|[[Levels_of_Evidence#Comparative_efficacy|Comparative Efficacy]]
 
−
|-
 
−
|[https://doi.org/10.1056/nejmoa2206660 Castellino et al. 2022 (COG AHOD1331)]
 
−
|2015-2019
 
−
| style="background-color:#1a9851" |Phase 3 (E-switch-ooc)
 
−
|[[#ABVE-PC|ABVE-PC]]
 
−
| style="background-color:#1a9850" |Superior EFS<br>EFS36: 92.1% vs 82.5%<br>(HR 0.41, 95% CI 0.25-0.67)
 
−
|-
 
−
|}
 
−
<div class="toccolours" style="background-color:#b3e2cd">
 
−
====Antibody-drug conjugate therapy====
 
−
*[[Brentuximab vedotin (Adcetris)]] 1.8 mg/kg (maximum dose of 180 mg) IV over 30 minutes once on day 1, '''given prior to chemotherapy'''
 
−
**Do NOT use In Line Filters
 
−
====Chemotherapy====
 
−
*[[Doxorubicin (Adriamycin)]] 25 mg/m<sup>2</sup> IV push or intermittent infusion once per day on days 1 & 2
 
−
**Concentration not to exceed 2 mg/mL
 
−
**IV push over 1 to 5 minutes or by intermittent infusion over 1 to 15 minutes; may prolong to 60 minutes if institutional policies mandate
 
−
*[[Vincristine (Oncovin)]] 1.4 mg/m<sup>2</sup> (maximum dose of 2.8 mg) IV once on day 8
 
−
*[[Etoposide (Vepesid)]] 125 mg/m<sup>2</sup> IV over 60 to 120 minutes once per day on days 1 to 3
 
−
**Rate should not exceed 300 mg/m<sup>2</sup>
 
−
*[[Cyclophosphamide (Cytoxan)]] 600 mg/m<sup>2</sup> IV over 30 to 60 minutes once per day on days 1 & 2
 
−
====Glucocorticoid therapy====
 
−
*[[Prednisone (Sterapred)]] 20 mg/m<sup>2</sup> PO twice per day on days 1 to 7
 
−
====Supportive therapy====
 
−
*[[Filgrastim (Neupogen)]] 5 mcg/kg SC (preferred) or IV once per day beginning on day 4, 5, 6, 7, 8, or 9, per institutional policy and continuing until ANC greater than 1000/uL
 
−
**Alternative: [[Pegfilgrastim (Neulasta)]] 100 mcg/kg (Maximum dose of 6 mg) SC once on day 4, 5, or 6
 
−
'''21-day cycle for 2 cycles, then response evaluation, then 21-day cycle for 3 cycles'''
 
−
</div></div>
 
−
===References===
 
−
# '''COG AHOD1331:''' Castellino SM, Pei Q, Parsons SK, Hodgson D, McCarten K, Horton T, Cho S, Wu Y, Punnett A, Dave H, Henderson TO, Hoppe BS, Charpentier AM, Keller FG, Kelly KM. Brentuximab Vedotin with Chemotherapy in Pediatric High-Risk Hodgkin's Lymphoma. N Engl J Med. 2022 Nov 3;387(18):1649-1660. [https://doi.org/10.1056/nejmoa2206660 link to original article] [https://pubmed.ncbi.nlm.nih.gov/36322844/ PubMed] NCT02166463
 
−
=Upfront Therapy, Intermediate Risk=
 
−
==ABVE-PC {{#subobject:918uu2|Regimen=1}}==
 
−
ABVE-PC: '''<u>A</u>'''driamycin (Doxorubicin), '''<u>B</u>'''leomycin, '''<u>V</u>'''incristine, '''<u>E</u>'''toposide, '''<u>P</u>'''rednisone, '''<u>C</u>'''yclophosphamide
 
−
<div class="toccolours" style="background-color:#eeeeee">
 
−
===Regimen {{#subobject:941bb2|Variant=1}}===
 
−
{| class="wikitable sortable" style="width: 60%; text-align:center;"
 
−
!style="width: 33%"|Study
 
−
!style="width: 33%"|Years of enrollment
 
−
!style="width: 33%"|[[Levels_of_Evidence#Evidence|Evidence]]
 
−
|-
 
−
|[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220044/ Friedman et al. 2014 (COG AHOD0031)]
 
−
|2002-2009
 
−
| style="background-color:#91cf61" |Non-randomized portion of phase 3 RCT
 
−
|-
 
−
|}
 
−
<div class="toccolours" style="background-color:#b3e2cd">
 
−
====Chemotherapy====
 
−
*[[Doxorubicin (Adriamycin)]] 25 mg/m<sup>2</sup> IV over 10 to 30 minutes once per day on days 1, 2
 
−
*[[Bleomycin (Blenoxane)]] 5 units/m<sup>2</sup> IV over 10 to 20 minutes or SC once on day 1, then 10 units/m<sup>2</sup> IV over 10 to 20 minutes or SC once on day 8
 
−
*[[Vincristine (Oncovin)]] 1.4 mg/m<sup>2</sup> (maximum dose of 2.8 mg) IV once per day on days 1, 8
 
−
*[[Etoposide (Vepesid)]] 125 mg/m<sup>2</sup> IV over 60 minutes once per day on days 1, 2, 3
 
−
*[[Cyclophosphamide (Cytoxan)]] 800 mg/m<sup>2</sup> IV over 60 minutes once on day 1
 
−
====Glucocorticoid therapy====
 
−
*[[Prednisone (Sterapred)]] 40 mg/m<sup>2</sup>/day PO divided twice per day or three times per day on days 1 to 7
 
−
'''21-day cycle for 2 cycles'''
 
−
</div>
 
−
<div class="toccolours" style="background-color:#cbd5e7">
 
−
====Subsequent treatment====
 
−
*COG AHOD0031, rapid early responders with CR: [[#ABVE-PC|ABVE-PC]] x 2, then [[#Radiation_therapy|IFRT]] versus [[#Observation_88|no further treatment]]
 
−
*COG AHOD0031, rapid early responders with less than CR: [[#ABVE-PC|ABVE-PC]] x 2, then [[#Radiation_therapy|IFRT]]
 
−
*COG AHOD0031, slow early responders: [[#ABVE-PC|ABVE-PC]] x 2, then [[#Radiation_therapy|IFRT]] versus [[#DECA|DECA]] x 2, then [[#ABVE-PC|ABVE-PC]] x 2, then [[#Radiation_therapy|IFRT]]
 
−
</div></div>
 
−
===References===
 
−
# '''COG AHOD0031:''' Friedman DL, Chen L, Wolden S, Buxton A, McCarten K, FitzGerald TJ, Kessel S, De Alarcon PA, Chen AR, Kobrinsky N, Ehrlich P, Hutchison RE, Constine LS, Schwartz CL; Children's Oncology Group. Dose-intensive response-based chemotherapy and radiation therapy for children and adolescents with newly diagnosed intermediate-risk Hodgkin lymphoma: a report from the Children's Oncology Group Study AHOD0031. J Clin Oncol. 2014 Nov 10;32(32):3651-8. Epub 2014 Oct 13. [https://doi.org/10.1200/jco.2013.52.5410 link to original article] '''does not contain dosing details''' [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220044/ link to PMC article] [https://pubmed.ncbi.nlm.nih.gov/25311218 PubMed] NCT00025259
 
−
==DECA {{#subobject:jqqcu2|Regimen=1}}==
 
−
DECA: '''<u>D</u>'''examethasone, '''<u>E</u>'''toposide, '''<u>C</u>'''isplatin, '''<u>A</u>'''ra-C (Cytarabine)
 
−
<div class="toccolours" style="background-color:#eeeeee">
 
−
===Regimen {{#subobject:94172v|Variant=1}}===
 
−
{| class="wikitable sortable" style="width: 60%; text-align:center;"
 
−
!style="width: 33%"|Study
 
−
!style="width: 33%"|Years of enrollment
 
−
!style="width: 33%"|[[Levels_of_Evidence#Evidence|Evidence]]
 
−
|-
 
−
|[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220044/ Friedman et al. 2014 (COG AHOD0031)]
 
−
|2002-2009
 
−
| style="background-color:#91cf61" |Non-randomized portion of phase 3 RCT
 
−
|-
 
−
|}
 
−
''Note: this is a component of a sequential treatment protocol; to our knowledge there are no references to support using it as a stand-alone treatment.''
 
−
<div class="toccolours" style="background-color:#cbd5e8">
 
−
====Preceding treatment====
 
−
*[[#ABVE-PC_2|ABVE-PC]] x 2, with slow early response
 
−
</div>
 
−
<div class="toccolours" style="background-color:#b3e2cd">
 
−
====Glucocorticoid therapy====
 
−
*[[Dexamethasone (Decadron)]] 10 mg/m<sup>2</sup> IV over 15 minutes on days 1, 2, '''given prior to etoposide/cytarabine'''
 
−
====Chemotherapy====
 
−
*[[Etoposide (Vepesid)]] 100 mg/m<sup>2</sup> IV over 3 hours once per day on days 1, 2
 
−
**Mix [[Etoposide (Vepesid)]] with [[Cytarabine (Ara-C)]] in D5W at an [[Etoposide (Vepesid)]] concentration of ≤ 0.4 mg/mL
 
−
*[[Cisplatin (Platinol)]] 90 mg/m<sup>2</sup> IV over 6 hours once on day 1
 
−
*[[Cytarabine (Ara-C)]] 3000 mg/m<sup>2</sup> IV over 3 hours on days 1, 2
 
−
**Mix [[Etoposide (Vepesid)]] with [[Cytarabine (Ara-C)]] in D5W at an [[Etoposide (Vepesid)]] concentration of ≤ 0.4 mg/mL
 
−
'''21-day cycle for 2 cycles'''
 
−
</div>
 
−
<div class="toccolours" style="background-color:#cbd5e7">
 
−
====Subsequent treatment====
 
−
*[[#ABVE-PC_2|ABVE-PC]] x 2, then [[#Radiation_therapy|IFRT]]
 
−
</div></div>
 
−
===References===
 
−
# '''COG AHOD0031:''' Friedman DL, Chen L, Wolden S, Buxton A, McCarten K, FitzGerald TJ, Kessel S, De Alarcon PA, Chen AR, Kobrinsky N, Ehrlich P, Hutchison RE, Constine LS, Schwartz CL; Children's Oncology Group. Dose-intensive response-based chemotherapy and radiation therapy for children and adolescents with newly diagnosed intermediate-risk Hodgkin lymphoma: a report from the Children's Oncology Group Study AHOD0031. J Clin Oncol. 2014 Nov 10;32(32):3651-8. Epub 2014 Oct 13. [https://doi.org/10.1200/jco.2013.52.5410 link to original article] '''does not contain dosing details''' [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220044/ link to PMC article] [https://pubmed.ncbi.nlm.nih.gov/25311218 PubMed] NCT00025259
 
−
=Upfront Therapy, Low Risk=
 
−
==OEPA (GPOD-HD-2002) {{#subobject:0e614f|Regimen=1}}==
 
−
OEPA: '''<u>O</u>'''ncovin (Vincristine), '''<u>E</u>'''toposide, '''<u>P</u>'''rednisone, '''<u>A</u>'''driamycin (Doxorubicin)
 
−
<div class="toccolours" style="background-color:#eeeeee">
 
−
===Regimen {{#subobject:25c262|Variant=1}}===
 
−
{| class="wikitable sortable" style="width: 60%; text-align:center;"
 
−
!style="width: 33%"|Study
 
−
!style="width: 33%"|Years of enrollment
 
−
!style="width: 33%"|[[Levels_of_Evidence#Evidence|Evidence]]
 
−
|-
 
−
|[https://doi.org/10.1200/jco.2009.26.9381 Mauz-Körholz et al. 2010 (GPOH-HD-2002)]
 
−
|2002-2005
 
−
| style="background-color:#91cf61" |Phase 2
 
−
|-
 
−
|}
 
−
''This regimen is meant for boys as it is potentially less gonadotoxic. The original protocol used three doses of dacarbazine per cycle but this was increased to four after a mid-protocol amendment. Patients with early-stage disease only received the OEPA portion, see text for details.''
 
−
====Chemotherapy====
 
−
*[[Vincristine (Oncovin)]] 1.5 mg/m<sup>2</sup> IV once per day on days 1, 8, 15
 
−
*[[Etoposide (Vepesid)]] 125 mg/m<sup>2</sup> IV once per day on days 2 to 6
 
−
*[[Doxorubicin (Adriamycin)]] 40 mg/m<sup>2</sup> IV once per day on days 1 & 15
 
−
====Glucocorticoid therapy====
 
−
*[[Prednisone (Sterapred)]] 60 mg/m<sup>2</sup> PO once per day on days 1 to 15
 
−
'''28-day cycle for 2 cycles'''
 
−
</div>
 
−
<div class="toccolours" style="background-color:#cbd5e7">
 
−
====Subsequent treatment====
 
−
*Treatment group 2: [[#COPDAC|COPDAC]] x 2
 
−
*Treatment group 3: [[#COPDAC|COPDAC]] x 4
 
−
</div></div>
 
−
===References===
 
−
# '''GPOH-HD-2002:''' Mauz-Körholz C, Hasenclever D, Dörffel W, Ruschke K, Pelz T, Voigt A, Stiefel M, Winkler M, Vilser C, Dieckmann K, Karlén J, Bergsträsser E, Fosså A, Mann G, Hummel M, Klapper W, Stein H, Vordermark D, Kluge R, Körholz D. Procarbazine-free OEPA-COPDAC chemotherapy in boys and standard OPPA-COPP in girls have comparable effectiveness in pediatric Hodgkin's lymphoma: the GPOH-HD-2002 study. J Clin Oncol. 2010 Aug 10;28(23):3680-6. Epub 2010 Jul 12. [https://doi.org/10.1200/jco.2009.26.9381 link to original article] '''contains dosing details in manuscript''' [https://pubmed.ncbi.nlm.nih.gov/20625128 PubMed] NCT00416832
 
−
=Consolidation therapy=
 
−
==Radiation therapy {{#subobject:b169ea|Regimen=1}}==
 
−
RT: '''<u>R</u>'''adiation '''<u>T</u>'''herapy
 
−
<div class="toccolours" style="background-color:#eeeeee">
 
−
===Regimen {{#subobject:dfa48c|Variant=1}}===
 
−
{| class="wikitable sortable" style="width: 100%; text-align:center;"
 
−
!style="width: 20%"|Study
 
−
!style="width: 20%"|Years of enrollment
 
−
!style="width: 20%"|[[Levels_of_Evidence#Evidence|Evidence]]
 
−
!style="width: 20%"|Comparator
 
−
!style="width: 20%"|[[Levels_of_Evidence#Comparative_efficacy|Comparative Efficacy]]
 
−
|-
 
−
|[https://doi.org/10.1200/JCO.2002.12.007 Nachman et al. 2002 (CCG 5942)]
 
−
|1995-1998
 
−
| style="background-color:#1a9851" |Phase 3 (C)
 
−
|[[Hodgkin_lymphoma_-_null_regimens#Observation|Observation]]
 
−
| style="background-color:#1a9850" |Superior EFS
 
−
|-
 
−
|[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2744567/ Schwartz et al. 2009 (POG P9425)]
 
−
|1997-2001
 
−
| style="background-color:#91cf61" |Phase 2
 
−
| style="background-color:#d3d3d3" |
 
−
| style="background-color:#d3d3d3" |
 
−
|-
 
−
|[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220044/ Friedman et al. 2014 (COG AHOD0031)]
 
−
|2002-2009
 
−
| style="background-color:#1a9851" |Phase 3 (C)
 
−
|[[Hodgkin_lymphoma_-_null_regimens#Observation|Observation]]
 
−
| style="background-color:#ffffbf" |Did not meet primary endpoint of EFS48
 
−
|-
 
−
|}
 
−
''This regimen is intended for pediatric patients, younger than 22 years old.''
 
−
<div class="toccolours" style="background-color:#cbd5e8">
 
−
====Preceding treatment====
 
−
*CCG 5942: [[#C-MOPP.2FABV|COPP-ABV hybrid]] x 4 or 6 or multi-drug therapy, depending on risk stratification
 
−
*POG P9425: [[#ABVE-PC|ABVE-PC]] x 3 to 5
 
−
*COG AHOD0031 RERs: [[#ABVE-PC|ABVE-PC]] x 4
 
−
*COG AHOD0031 SERs: [[#ABVE-PC|ABVE-PC]] x 4 versus [[#ABVE-PC|ABVE-PC]] x 2, then DECA x 2, then [[#ABVE-PC|ABVE-PC]] x 2
 
−
</div>
 
−
<div class="toccolours" style="background-color:#b3e2cd">
 
−
====Radiotherapy====
 
−
*[[External beam radiotherapy]] 21 Gy in 12 to 14 fractions of 1.5 to 1.75 Gy per fraction
 
−
</div></div>
 
−
===References===
 
−
# '''CCG 5942:''' Nachman JB, Sposto R, Herzog P, Gilchrist GS, Wolden SL, Thomson J, Kadin ME, Pattengale P, Davis PC, Hutchinson RJ, White K; Children's Cancer Group. Randomized comparison of low-dose involved-field radiotherapy and no radiotherapy for children with Hodgkin's disease who achieve a complete response to chemotherapy. J Clin Oncol. 2002 Sep 15;20(18):3765-71. [https://doi.org/10.1200/JCO.2002.12.007 link to original article] '''contains dosing details in manuscript''' [https://pubmed.ncbi.nlm.nih.gov/12228196 PubMed] NCT00592111
 
−
## '''Update:''' Wolden SL, Chen L, Kelly KM, Herzog P, Gilchrist GS, Thomson J, Sposto R, Kadin ME, Hutchinson RJ, Nachman J. Long-term results of CCG 5942: a randomized comparison of chemotherapy with and without radiotherapy for children with Hodgkin's lymphoma--a report from the Children's Oncology Group. J Clin Oncol. 2012 Sep 10;30(26):3174-80. Epub 2012 May 29. [https://doi.org/10.1200/JCO.2011.41.1819 link to original article] [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434976/ link to PMC article] [https://pubmed.ncbi.nlm.nih.gov/22649136 PubMed]
 
−
# '''POG P9425:''' Schwartz CL, Constine LS, Villaluna D, London WB, Hutchison RE, Sposto R, Lipshultz SE, Turner CS, deAlarcon PA, Chauvenet A. A risk-adapted, response-based approach using ABVE-PC for children and adolescents with intermediate- and high-risk Hodgkin lymphoma: the results of P9425. Blood. 2009 Sep 3;114(10):2051-9. Epub 2009 Jul 7. Erratum: in Blood 2016 128:605 [http://www.bloodjournal.org/content/114/10/2051.long link to original article] '''contains dosing details in manuscript''' [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2744567/ link to PMC article] [https://pubmed.ncbi.nlm.nih.gov/19584400 PubMed] NCT00005578
 
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# '''COG AHOD0031:''' Friedman DL, Chen L, Wolden S, Buxton A, McCarten K, FitzGerald TJ, Kessel S, De Alarcon PA, Chen AR, Kobrinsky N, Ehrlich P, Hutchison RE, Constine LS, Schwartz CL. Dose-intensive response-based chemotherapy and radiation therapy for children and adolescents with newly diagnosed intermediate-risk Hodgkin lymphoma: a report from the Children's Oncology Group Study AHOD0031. J Clin Oncol. 2014 Nov 10;32(32):3651-8. Epub 2014 Oct 13. [https://doi.org/10.1200/jco.2013.52.5410 link to original article] '''does not contain dosing details''' [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220044/ link to PMC article] [https://pubmed.ncbi.nlm.nih.gov/25311218 PubMed] NCT00025259
 
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[[Category:Hodgkin lymphoma regimens]]
 
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[[Category:Disease-specific pages]]
 
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[[Category:Aggressive lymphomas]]
 
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[[Category:Pediatric hematologic neoplasms]]
 

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