Difference between revisions of "Pidilizumab (CT-011)"
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=Mechanism of action= | =Mechanism of action= | ||
| + | From [http://www.cancer.gov/drugdictionary?CdrID=573227 NCI Drug Dictionary]: A humanized monoclonal antibody directed against human PD-1 (programmed cell death 1; PDCD1), with immunomodulating and antitumor activities. Pidilizumab blocks interaction between the receptor PD-1 with its ligands, PD-1 ligand 1 (PD-1L1) and PD-1 ligand 2 (PD-1L2), resulting in the attenuation of apoptotic processes in lymphocytes, primarily effector/memory T cells, and the augmentation of the anti-tumor activities of NK cells. | ||
=Preliminary data= | =Preliminary data= | ||
Revision as of 16:26, 21 February 2015
Mechanism of action
From NCI Drug Dictionary: A humanized monoclonal antibody directed against human PD-1 (programmed cell death 1; PDCD1), with immunomodulating and antitumor activities. Pidilizumab blocks interaction between the receptor PD-1 with its ligands, PD-1 ligand 1 (PD-1L1) and PD-1 ligand 2 (PD-1L2), resulting in the attenuation of apoptotic processes in lymphocytes, primarily effector/memory T cells, and the augmentation of the anti-tumor activities of NK cells.
Preliminary data
Diffuse large B-cell lymphoma
Regimen
Phase II
Treatment is to begin within 30 to 90 days after autologous stem-cell transplant for chemoresponsive disease.
- Pidilizumab (CT-011) 1.5 mg/kg IV once
Supportive medications:
- Acetaminophen (Tylenol) or Ibuprofen prior to Pidilizumab (CT-011)
- Diphenhydramine (Benadryl) or Promethazine (Phenergan) prior to Pidilizumab (CT-011)
42-day cycle x 3 cycles
References
- Armand P, Nagler A, Weller EA, Devine SM, Avigan DE, Chen YB, Kaminski MS, Kent Holland H, Winter JN, Mason JR, Fay JW, Rizzieri DA, Hosing CM, Ball ED, Uberti JP, Lazarus HM, Mapara MY, Gregory SA, Timmerman JM, Andorsky D, Or R, Waller EK, Rotem-Yehudar R, Gordon LI. Disabling Immune Tolerance by Programmed Death-1 Blockade With Pidilizumab After Autologous Hematopoietic Stem-Cell Transplantation for Diffuse Large B-Cell Lymphoma: Results of an International Phase II Trial. J Clin Oncol. 2013 Oct 14. [Epub ahead of print] link to original article contains verified protocol PubMed
Follicular lymphoma
- Westin JR, Chu F, Zhang M, Fayad LE, Kwak LW, Fowler N, Romaguera J, Hagemeister F, Fanale M, Samaniego F, Feng L, Baladandayuthapani V, Wang Z, Ma W, Gao Y, Wallace M, Vence LM, Radvanyi L, Muzzafar T, Rotem-Yehudar R, Davis RE, Neelapu SS. Safety and activity of PD1 blockade by pidilizumab in combination with rituximab in patients with relapsed follicular lymphoma: a single group, open-label, phase 2 trial. Lancet Oncol. 2014 Jan;15(1):69-77. link to original article Epub 2013 Dec 11. PubMed