Difference between revisions of "Hydroxyurea (Hydrea)"
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*[[Essential thrombocythemia]] | *[[Essential thrombocythemia]] | ||
*[[Head and neck cancer]] | *[[Head and neck cancer]] | ||
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==Patient drug information== | ==Patient drug information== | ||
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[[Category:Essential thrombocythemia medications]] | [[Category:Essential thrombocythemia medications]] | ||
[[Category:Head and neck cancer medications]] | [[Category:Head and neck cancer medications]] | ||
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[[Category:Drugs FDA approved in 1967]] | [[Category:Drugs FDA approved in 1967]] | ||
Revision as of 01:42, 21 February 2015
General information
Class/mechanism: Exact mechanism unclear, but data suggests that hydroxyurea inhibits DNA synthesis by inhibiting ribonucleotide reductase, which inhibits cancer cell growth. May sensitize tumors to radiation by keeping cells in the G1 phase of the cell cycle, where they are most vulnerable to radiation, and/or by interfering with DNA repair processes. Does not appear to affect RNA and protein synthesis.[1][2]
Route: PO
Extravasation: n/a
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
- Acute myeloid leukemia
- Central nervous system (CNS) cancer
- Cervical cancer
- Essential thrombocythemia
- Head and neck cancer
- Polycythemia vera
Patient drug information
- Hydroxyurea (Hydrea) patient drug information (Chemocare)[3]
- Hydroxyurea (Hydrea) patient drug information (UpToDate)[4]
History of changes in FDA indication
- 12/7/1967: Initial FDA approval
Also known as
| Synonyms | |||||||
|---|---|---|---|---|---|---|---|
| APO-Hydroxyurea | Biosupressin | Cytodrox | Dhnp | Droxia | |||
| Droxiurea | Durea | GEN-Hydroxyurea | Hidrea | Hidroxiurea Delta Farma | |||
| Hidroxiurea Martian | Hidroxiurea Microsules | Hondrea | Hydab | Hydrea | |||
| Hydrine | Hydrourea | Hydroxycarbam | Hydroxycarbamid | Hydroxycarbamide | |||
| Hydroxyurea | Hydroxyurea Medac | Hytas | Litalir | Myelostat | |||
| Mylocel | Neodrea | Onco Carbide | Syrea | Ureax | |||