Difference between revisions of "Factor XIII concentrate, human (Corifact)"
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(Created page with "Also known as coagulation factor 13, FXIII. ==General information== Class/mechanism: Human factor XIII; in the coagulation cascade, factor XIII is activated by thrombin (factor ...") |
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==General information== | ==General information== | ||
| − | Class/mechanism: Human factor XIII; in the coagulation cascade, factor XIII is activated by thrombin (factor IIa) to factor XIIIa, which promotes cross-linking of fibrin. | + | Class/mechanism: Human factor XIII; in the coagulation cascade, factor XIII is activated by thrombin (factor IIa) to factor XIIIa, which promotes cross-linking of fibrin. Factor XIIIa promotes stabilization of the fibrin clot by cross-linking alpha-2 plasmin inhibitor to the alpha chain of fibrin. Clinically used in patients with congenital factor XIII deficiency.<ref name="insert">[http://www.corifact.com/docs/Corifact-Prescribing-Information.pdf Factor XIII concentrate, human (Corifact) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/factorxiii.pdf Factor XIII concentrate, human (Corifact) package insert (locally hosted backup)]</ref><ref>[http://www.corifact.com/ Corifact manufacturer's website]</ref> |
<br>Route: IV | <br>Route: IV | ||
<br>Extravasation: no information | <br>Extravasation: no information | ||
| − | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. | + | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> |
==Patient drug information== | ==Patient drug information== | ||
*[http://www.corifact.com/docs/Corifact-Prescribing-Information.pdf#page=5 Factor XIII concentrate, human (Corifact) package insert PDF page 5]<ref>[http://www.corifact.com/docs/Corifact-Prescribing-Information.pdf#page=5 Factor XIII concentrate, human (Corifact) package insert PDF page 5]</ref> | *[http://www.corifact.com/docs/Corifact-Prescribing-Information.pdf#page=5 Factor XIII concentrate, human (Corifact) package insert PDF page 5]<ref>[http://www.corifact.com/docs/Corifact-Prescribing-Information.pdf#page=5 Factor XIII concentrate, human (Corifact) package insert PDF page 5]</ref> | ||
*[http://www.uptodate.com/contents/factor-xiii-concentrates-patient-drug-information Factor XIII concentrate, human (Corifact) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/factor-xiii-concentrates-patient-drug-information Factor XIII concentrate, human (Corifact) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/factor-xiii-concentrates-patient-drug-information Factor XIII concentrate, human (Corifact) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/factor-xiii-concentrates-patient-drug-information Factor XIII concentrate, human (Corifact) patient drug information (UpToDate)]</ref> | ||
| + | |||
| + | ==Also known as== | ||
| + | *'''Generic names:''' coagulation factor 13, FXIII | ||
| + | *'''Brand name:''' Corifact | ||
==References== | ==References== | ||
<references/> | <references/> | ||
| + | |||
| + | [[Category:Fractionated plasma products]] | ||
| + | [[Category:Intravenous medications]] | ||
| + | [[Category:Inherited coagulopathy medications]] | ||
| + | [[Category:Hemostasis medications]] | ||
| + | [[Category:Coagulation factors]] | ||
| + | |||
| + | [[Category:Hematology medications]] | ||
Revision as of 01:54, 1 June 2023
General information
Class/mechanism: Human factor XIII; in the coagulation cascade, factor XIII is activated by thrombin (factor IIa) to factor XIIIa, which promotes cross-linking of fibrin. Factor XIIIa promotes stabilization of the fibrin clot by cross-linking alpha-2 plasmin inhibitor to the alpha chain of fibrin. Clinically used in patients with congenital factor XIII deficiency.[1][2][3]
Route: IV
Extravasation: no information
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Patient drug information
- Factor XIII concentrate, human (Corifact) package insert PDF page 5[4]
- Factor XIII concentrate, human (Corifact) patient drug information (UpToDate)[5]
Also known as
- Generic names: coagulation factor 13, FXIII
- Brand name: Corifact
References
- ↑ 1.0 1.1 Factor XIII concentrate, human (Corifact) package insert
- ↑ Factor XIII concentrate, human (Corifact) package insert (locally hosted backup)
- ↑ Corifact manufacturer's website
- ↑ Factor XIII concentrate, human (Corifact) package insert PDF page 5
- ↑ Factor XIII concentrate, human (Corifact) patient drug information (UpToDate)