Difference between revisions of "Acalabrutinib (Calquence)"
m |
|||
| Line 8: | Line 8: | ||
==Diseases for which it is established ''(work in progress)''== | ==Diseases for which it is established ''(work in progress)''== | ||
*[[Chronic lymphocytic leukemia]] | *[[Chronic lymphocytic leukemia]] | ||
| − | |||
| − | |||
*[[Mantle cell lymphoma]] | *[[Mantle cell lymphoma]] | ||
| Line 21: | Line 19: | ||
*11/21/2019: Approved for adults with [[Chronic lymphocytic leukemia|chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL)]]. ''(Based on ELEVATE TN and ASCEND)'' | *11/21/2019: Approved for adults with [[Chronic lymphocytic leukemia|chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL)]]. ''(Based on ELEVATE TN and ASCEND)'' | ||
| + | ==History of changes in EMA indication== | ||
| + | *11/5/2020: Initial authorization | ||
==Also known as== | ==Also known as== | ||
*'''Code name:''' ACP-196 | *'''Code name:''' ACP-196 | ||
| Line 30: | Line 30: | ||
[[Category:Drugs]] | [[Category:Drugs]] | ||
[[Category:Oral medications]] | [[Category:Oral medications]] | ||
| − | |||
[[Category:BTK inhibitors]] | [[Category:BTK inhibitors]] | ||
| Line 38: | Line 37: | ||
[[Category:FDA approved in 2017]] | [[Category:FDA approved in 2017]] | ||
| + | [[Category:EMA approved in 2020]] | ||
Revision as of 22:26, 2 January 2023
General information
Class/mechanism: Irreversible inhibitor of Bruton's tyrosine kinase (BTK), which is an enzyme that participates in the B-cell receptor (BCR) signal cascade and cytokine receptor pathways. BCR signaling is believed to promote cell proliferation, adhesion, and survival in B-cell malignancies. Inhibition of BTK interferes with the processes above, as well as B-cell chemotaxis and trafficking. More specific to BTK than the first-generation drug ibrutinib.[1][2][3]
Route: PO
Extravasation: n/a
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is established (work in progress)
Patient drug information
- Acalabrutinib (Calquence) package insert[1]
- Acalabrutinib (Calquence) patient drug information (Chemocare)[4]
- Acalabrutinib (Calquence) patient drug information (UpToDate)[5]
History of changes in FDA indication
- 10/31/2017: Granted accelerated approval for treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. (Based on ACE-LY-004)
- 11/21/2019: Approved for adults with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). (Based on ELEVATE TN and ASCEND)
History of changes in EMA indication
- 11/5/2020: Initial authorization
Also known as
- Code name: ACP-196
- Brand name: Calquence