Difference between revisions of "Epirubicin (Ellence)"
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(Created page with "==General information== Class/mechanism: <ref name="insert">[http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/050778s015s017s018lbl.pdf Epirubicin (Ellence) package inser...") |
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==General information== | ==General information== | ||
| − | Class/mechanism: <ref name="insert">[http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/050778s015s017s018lbl.pdf Epirubicin (Ellence) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/epirubicin.pdf Epirubicin (Ellence) package insert (locally hosted backup)]</ref> | + | Class/mechanism: Anthracycline; binds and intercalates DNA, which triggers DNA cleavage by topoisomerase II; inhibits DNA/RNA synthesis. Inhibits DNA helicase activity, preventing enzymatic separation of double-stranded DNA.<ref name="insert">[http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/050778s015s017s018lbl.pdf Epirubicin (Ellence) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/epirubicin.pdf Epirubicin (Ellence) package insert (locally hosted backup)]</ref> |
| − | <br>Route: | + | <br>Route: IV |
| − | <br>Extravasation: | + | <br>Extravasation: [[vesicant]] |
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the package insert<ref name="insert"></ref>. | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the package insert<ref name="insert"></ref>. | ||
Revision as of 16:04, 24 December 2011
General information
Class/mechanism: Anthracycline; binds and intercalates DNA, which triggers DNA cleavage by topoisomerase II; inhibits DNA/RNA synthesis. Inhibits DNA helicase activity, preventing enzymatic separation of double-stranded DNA.[1][2]
Route: IV
Extravasation: vesicant
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the package insert[1].
Patient drug information
- Epirubicin (Ellence) patient drug information (Chemocare)[3]
- Epirubicin (Ellence) patient drug information (UpToDate)[4]