Difference between revisions of "Trabectedin (Yondelis)"
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*[http://www.uptodate.com/contents/trabectedin-patient-drug-information Trabectedin (Yondelis) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/trabectedin-patient-drug-information Trabectedin (Yondelis) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/trabectedin-patient-drug-information Trabectedin (Yondelis) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/trabectedin-patient-drug-information Trabectedin (Yondelis) patient drug information (UpToDate)]</ref> | ||
| + | ==History of changes in FDA indication== | ||
| + | * 9/30/2004: Granted orphan status for treatment of [[Sarcoma | soft tissue sarcoma]]. | ||
| + | * 3/29/2005: Granted orphan status for treatment of patients with [[Ovarian cancer | ovarian cancer]]. | ||
==References== | ==References== | ||
<references/> | <references/> | ||
| + | |||
| + | [[Category:Drug index]] | ||
| + | [[Category:Chemotherapy]] | ||
| + | [[Category:Vesicant chemotherapy]] | ||
| + | [[Category:Orphan drug]] | ||
| + | |||
| + | [[Category:Ovarian cancer medications]] | ||
| + | [[Category:Sarcoma medications]] | ||
Revision as of 16:22, 9 November 2014
Also known as ecteinascidin 743 or ET-743.
General information
Class/mechanism: Binds to the minor groove of DNA, which distorts the DNA helix and its major groove. This binding interrupts normal cell function and interferes with the expression of several several transcription factors, DNA binding proteins, and DNA repair mechanisms, which interrupts cell cycle and leads to tumor death.[1][2]
Route: IV
Extravasation: vesicant
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Patient drug information
- Trabectedin (Yondelis) patient drug information from manufacturer[3]
- Trabectedin (Yondelis) patient drug information (UpToDate)[4]
History of changes in FDA indication
- 9/30/2004: Granted orphan status for treatment of soft tissue sarcoma.
- 3/29/2005: Granted orphan status for treatment of patients with ovarian cancer.