Difference between revisions of "Tivozanib (Fotivda)"
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=Mechanism of action= | =Mechanism of action= | ||
| − | From the [http://www.cancer.gov/publications/dictionaries/cancer-drug?CdrID=561728 NCI Drug Dictionary]: An orally bioavailable inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2 and 3 with potential antiangiogenic and antineoplastic activities. Tivozanib binds to and inhibits VEGFRs 1, 2 and 3, which may result in the inhibition of endothelial cell migration and proliferation, inhibition of tumor angiogenesis and tumor cell death. | + | From the [http://www.cancer.gov/publications/dictionaries/cancer-drug?CdrID=561728 NCI Drug Dictionary]: An orally bioavailable inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2 and 3 with potential antiangiogenic and antineoplastic activities. Tivozanib binds to and inhibits VEGFRs 1, 2 and 3, which may result in the inhibition of endothelial cell migration and proliferation, inhibition of tumor angiogenesis and tumor cell death.<ref name="insert">[https://www.fotivdahcp.com/fotivdapi.pdf Tivozanib (Fotivda) package insert]</ref><ref>[[:File:Tivozanib.pdf | Tivozanib (Fotivda) package insert (locally hosted backup)]]</ref><ref>[https://www.fotivda.com/ Fotivda manufacturer's website]</ref> |
| − | =Diseases for which it is used= | + | ==Diseases for which it is used== |
*[[Renal cell carcinoma]] | *[[Renal cell carcinoma]] | ||
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| + | ==Patient drug information== | ||
| + | *[https://www.fotivdahcp.com/fotivdapi.pdf Tivozanib (Fotivda) package insert]<ref name="insert"></ref> | ||
| + | *[http://www.uptodate.com/contents/tivozanib-patient-drug-information Tivozanib (Fotivda) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/tivozanib-patient-drug-information Tivozanib (Fotivda) patient drug information (UpToDate)]</ref> | ||
==History of changes in FDA approval== | ==History of changes in FDA approval== | ||
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*'''Code name:''' AV-951 | *'''Code name:''' AV-951 | ||
*'''Brand name:''' Fotivda | *'''Brand name:''' Fotivda | ||
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| + | ==References== | ||
| + | <references/> | ||
[[Category:Drugs]] | [[Category:Drugs]] | ||
Revision as of 23:55, 31 December 2021
Mechanism of action
From the NCI Drug Dictionary: An orally bioavailable inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2 and 3 with potential antiangiogenic and antineoplastic activities. Tivozanib binds to and inhibits VEGFRs 1, 2 and 3, which may result in the inhibition of endothelial cell migration and proliferation, inhibition of tumor angiogenesis and tumor cell death.[1][2][3]
Diseases for which it is used
Patient drug information
History of changes in FDA approval
- 3/10/2021: Approved for adult patients with relapsed or refractory advanced renal cell carcinoma (RCC) following two or more prior systemic therapies.
Also known as
- Code name: AV-951
- Brand name: Fotivda